CD1 molecules are glycoproteins that present lipid antigens at the cell surface for
immunological recognition by specialized populations of T lymphocytes. Prior experimental …

CDl is a family of cell surface glycoproteins that are related in structure and evolutionary
origin to the major histocompatibility complex (MHC)-encoded antigen-presenting …

CD1d is an MHC class I-like membrane glycoprotein that presents lipid Ags to NKT cells.
Despite intensive biochemical, genetic, and structural studies, the endogenous lipids …

Recently, different members of the CD1 family of MHC-like molecules have been shown to
sample different intracellular compartments to present lipid and glycolipid antigens to T cells …

We have purified soluble mouse and human CD1d molecules to assess the structural
requirements for lipid antigen presentation by CD1. Plate-bound CD1d molecules from …

Self‐glycosphingolipids bind to surface CD1 molecules and are readily displaced by other
CD1 ligands. This capacity to exchange antigens at the cell surface is not common to other …

The CD1 family consists of five proteins that are related to the peptide-presenting MHC class
I family. T cells can recognize the presentation of both foreign and self-derived lipids on four …

Highlights•Human CD1 molecules present a diverse, overlapping repertoire of endogenous
lipids.•CD1 specific T cells comprise a significant percentage of blood αβ T cells.•Many CD1 …

The CD1 family consists of lipid antigen-presenting molecules, which include group I CD1a,
CD1b, and CD1c and group II CD1d proteins. Topologically, they resemble the classical …

The paradigm that T cells recognize peptide antigens presented by major histocompatibility
complex class I and class II molecules has been a guiding principle in the development of …