We previously demonstrated that a critical 35 bp region 3'of the AAUAAA is required for
rabbit (3-globln mRNA 3'end formation. Recently, we synthesized and tested sequence …

Abstract The sequence AAUAAA, found 11–30 base pairs (bp) upstream of the poly (A) site
of most non-histone eukaryotic messenger RNAs (mRNAs) 1 forms an essential part of the …

We constructed and analyzed a synthetic poly (A)(SPA) site that was based on the highly
efficient poly (A) signal of the rabbit beta-globin gene. By use of the SPA, we demonstrate …

We have conducted an extensive linker substitution analysis of the polyadenylation signal
from a pea rbcS gene. From these studies, we can identify at least two, and perhaps three …

Time after infection (h) Page 1 NATURE NEW BIOLOGY VOL. 233 SEPTEMBER 8 1971 4 %
Table 2 Effect of SV40 and 5-Fluoro 2-deoxyuridine (FUdR) Addition on Autoradiography …

Abstract Splicing and 3′‐end processing (including cleavage and polyadenylation) of
vertebrate pre‐mRNAs are tightly coupled events that contribute to the extensive molecular …

ABSTRACT Messenger RNA (mRNA) 3′ end formation is a nuclear process through which
all eukaryotic primary transcripts are endonucleolytically cleaved and most of them acquire a …

The majority of eukaryotic messenger RNA precursors (pre-mRNAs) undergo cleavage and
polyadenylation at their 3′ end. This canonical 3′-end processing depends on sequence …

From the date of its discovery in 1970, the 3'poly (A) tail of eukaryotic mRNA has taken on
the character of a structure in search of a function. Candidate functions favored in those far …

In principle, the formation of the 3 end of a eukaryotic mRNA is a simple process. At a
minimum, it involves the hydrolysis of a single phosphodiester bond in the nascent …