Investigating the function of Fal1/eIF4AIII in S. pombe

A Colella - 2020 - etheses.bham.ac.uk
The Exon Junction Complex (EJC) is a protein complex formed by a core of three proteins,
eIF4AIII, MAGO, Y14, which is cotranscriptionally deposited on spliced mRNAs in …

[HTML][HTML] Exon junction complex proteins bind nascent transcripts independently of pre-mRNA splicing in Drosophila melanogaster

SR Choudhury, AK Singh, T McLeod, M Blanchette… - Elife, 2016 - elifesciences.org
Although it is currently understood that the exon junction complex (EJC) is recruited on
spliced mRNA by a specific interaction between its central protein, eIF4AIII, and splicing …

Human eIF4AIII interacts with an eIF4G-like partner, NOM1, revealing an evolutionarily conserved function outside the exon junction complex

A Alexandrov, D Colognori, JA Steitz - Genes & development, 2011 - genesdev.cshlp.org
Despite the lack of an exon junction complex (EJC), Saccharomyces cerevisiae contains
Fal1p, a DEAD-box helicase highly homologous to eIF4AIII. We show that yeast Fal1p is …

[HTML][HTML] The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA

F Bono, J Ebert, E Lorentzen, E Conti - Cell, 2006 - cell.com
The exon junction complex (EJC) plays a major role in posttranscriptional regulation of
mRNA in metazoa. The EJC is deposited onto mRNA during splicing and is transported to …

[HTML][HTML] Exon junction complex components Y14 and Mago still play a role in budding yeast

A Boisramé, H Devillers, D Onesime, F Brunel… - Scientific reports, 2019 - nature.com
Since their divergence from Pezizomycotina, the mRNA metabolism of budding yeasts have
undergone regressive evolution. With the dramatic loss of introns, a number of quality …

[图书][B] The Dynamic Fate of the Exon Junction Complex

RD Patton - 2020 - search.proquest.com
Abstract The Exon Junction Complex, or EJC, is a group of proteins deposited on mRNA
upstream of exon-exon junctions during splicing, and which stays with the mRNA up until …

eIF4A3 is a novel component of the exon junction complex

CC Chan, J Dostie, MD Diem, W Feng, M Mann… - Rna, 2004 - rnajournal.cshlp.org
The exon junction complex (EJC) is a protein complex that assembles near exon–exon
junctions of mRNAs as a result of splicing. EJC proteins play important roles in postsplicing …

[HTML][HTML] Transcriptome-wide modulation of splicing by the exon junction complex

Z Wang, V Murigneux, H Le Hir - Genome biology, 2014 - Springer
Background The exon junction complex (EJC) is a dynamic multi-protein complex deposited
onto nuclear spliced mRNAs upstream of exon-exon junctions. The four core proteins …

Perispeckles are major assembly sites for the exon junction core complex

E Daguenet, A Baguet, S Degot… - Molecular Biology of …, 2012 - Am Soc Cell Biol
The exon junction complex (EJC) is loaded onto mRNAs as a consequence of splicing and
regulates multiple posttranscriptional events. MLN51, Magoh, Y14, and eIF4A3 form a highly …

The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity

L Ballut, B Marchadier, A Baguet, C Tomasetto… - Nature structural & …, 2005 - nature.com
The multiprotein exon junction complex (EJC) is assembled on mRNAs as a consequence of
splicing. EJC core components maintain a stable grip on mRNAs even as the overall EJC …