[HTML][HTML] Comparative effects of estrogen, raloxifene and tamoxifen on endothelial dysfunction, inflammatory markers and oxidative stress in ovariectomized rats

AZ Lamas, IF Caliman, PLM Dalpiaz, AF de Melo Jr… - Life sciences, 2015 - Elsevier
Aim Endothelial dysfunction is considered a premature indication of atherosclerosis and
vessel damage and is present in the postmenopausal period. This study compares the …

Effect of raloxifene and atorvastatin in atherosclerotic process in ovariectomized rats

B Çetinkaya Demir, Y Uyar, K Özbilgin… - Journal of Obstetrics …, 2013 - Wiley Online Library
Aim: The goal of this study was to investigate the combined effects of raloxifene and
atorvastatin in aged ovariectomized rats during endothelial dysfunction and atherosclerotic …

Raloxifene prevents endothelial dysfunction in aging ovariectomized female rats

CM Wong, X Yao, CL Au, SY Tsang, KP Fung… - Vascular …, 2006 - Elsevier
Lack of an appropriate animal model has delayed the better understanding of mechanisms
related to higher cardiovascular risk in women after menopause. The aging female rat may …

[HTML][HTML] Endothelial relaxation mechanisms and oxidative stress are restored by atorvastatin therapy in ovariectomized rats

IF Caliman, AZ Lamas, PLM Dalpiaz, ARS Medeiros… - PLoS …, 2013 - journals.plos.org
The studies on hormone replacement therapy (HRT) in females with estrogen deficiency are
not conclusive. Thus, non-estrogen therapies, such as atorvastatin (ATO), could be new …

[HTML][HTML] Aerobic exercise training prevents the onset of endothelial dysfunction via increased nitric oxide bioavailability and reduced reactive oxygen species in an …

VAVN Braga, GK Couto, MC Lazzarin, LV Rossoni… - PLoS …, 2015 - journals.plos.org
Objective Previous studies have shown that estrogen deficiency, arising in postmenopause,
promotes endothelial dysfunction. This study evaluated the effects of aerobic exercise …

Long-term effects of ovariectomy and estrogen replacement treatment on endothelial function in mature rats

F Moien-Afshari, E Kenyon, JC Choy, B Battistini… - Maturitas, 2003 - Elsevier
Objectives: Estrogen replacement therapy (ERT) improves blood flow through various
mechanisms including an augmented release of nitric oxide (NO). We report on the long …

Vascular effects of ovariectomy and chronic oestrogen treatment in rats: controversy or experimental protocol diversity?

T Chataigneau, VB Schini‐Kerth - British Journal of …, 2005 - Wiley Online Library
Several clinical studies have indicated that oestrogens have protective properties on the
cardiovascular system. Although the beneficial effect has been attributable, at least in part, to …

[HTML][HTML] The phytoestrogen α-zearalenol reverses endothelial dysfunction induced by oophorectomy in rats

D Altavilla, A Saitta, M Galeano, G Squadrito… - Laboratory …, 2001 - Elsevier
It has been shown recently that α-zearalenol, a resorcyclic acid lactone, prevents bone loss
in a rat model of postmenopausal bone loss. We have therefore investigated the effects of …

17β-Estradiol prevents oxidative stress and decreases blood pressure in ovariectomized rats

I Hernández, JL Delgado, J Díaz… - American Journal …, 2000 - journals.physiology.org
In this study, we tested whether estrogen deficiency is associated with oxidative stress and
decreased nitric oxide (NO) production, which could be responsible for an increased blood …

Endothelial function and menopause: effects of raloxifene administration

N Colacurci, D Manzella, F Fornaro… - The Journal of …, 2003 - academic.oup.com
Postmenopausal women have more severe endothelial dysfunction than premenopausal
women. In the present study, we evaluated the possible beneficial effect of raloxifene …