Background Malignant gliomas, the most common malignant brain tumors in adults,
represent a heterogeneous group of diseases with poor prognosis. Retroviruses can cause …

Retroviral tagging previously identified putative cancer-causing genes in a mouse brain
tumor model where a recombinant Moloney murine leukemia virus encoding the platelet …

Malignant primary brain tumors, gliomas, often overexpress both platelet-derived growth
factor (PDGF) ligands and receptors providing an autocrine and/or paracrine boost to tumor …

Background Gliomas are thought to form by clonal expansion from a single cell-of-origin,
and progression-associated mutations to occur in its progeny cells. Glioma progression is …

In primary brain tumors, oncogenes are frequently amplified and maintained on
extrachromosomal DNA as double minutes (DM), but the underlying mechanisms remain …

Glioblastomas are the most common and malignant astrocytic brain tumors in human adults.
The tumor suppressor gene TP53 is commonly mutated and/or lost in astrocytic brain tumors …

BACKGROUND: Alpha-type platelet-derived growth factor receptor (PDGFRα) is a cell
surface tyrosine kinase receptor for members of the platelet-derived growth factor family …

Background Mouse models of glioblastoma (GBM), the most aggressive primary brain tumor,
are critical for understanding GBM pathology and can contribute to the preclinical evaluation …

Recent collaborative, large-scale genomic profiling of the most common and aggressive
brain tumor glioblastoma multiforme (GBM) has significantly advanced our understanding of …

Purpose Diffuse intrinsic pontine glioma (DIPG) is one of the most devastating of pediatric
malignancies and one for which no effective therapy exists. A major contributor to the failure …