Innate and acquired resistances to therapeutic agents are responsible for the failure of
cancer treatments. Due to the multifactorial nature of resistance, the identification of new …

Highlights•Drug resistance of cancer cells, which results in treatment failure, is a major
concern in medical oncology.•Ca 2+ plays an important role in acquired drug resistance by …

Globally, cancer, as a major public health concern, poses a severe threat to people's well-
being. Advanced and specialized therapies can now cure the majority of people with early …

The calcium signal is implicated in a variety of processes important in tumor progression (eg
proliferation and invasiveness). The calcium signal has also been shown to be important in …

ABSTRACT Introduction The Ca2+ signaling toolkit is currently under investigation as a
potential target for addressing the threat of cancer. A growing body of evidence suggests …

The calcium signal is a powerful and multifaceted tool by which cells can achieve specific
outcomes. Cellular machinery important in tumour progression is often driven or influenced …

Cancer is a main public health problem all over the world. It affects millions of humans no
matter their age, gender, education, or social status. Although chemotherapy is the main …

Ca2+ is a ubiquitous cellular signal. Altered expression of specific Ca2+ channels and
pumps are characterizing features of some cancers. The ability of Ca2+ to regulate both cell …

The intracellular calcium ions (Ca 2+) act as second messenger to regulate gene
transcription, cell proliferation, migration and death. Accumulating evidences have …

Cancer is caused by excessive cell proliferation and a propensity to avoid cell death, while
the spread of cancer is facilitated by enhanced cellular migration, invasion, and …