Psoriasis is a chronic inflammatory disorder of the skin. Accumulating evidence indicates
that the Rel gene, a member of the NF-κB family, is a risk factor for the disease. We sought to …

Psoriasis is a common immune-mediated, chronic, inflammatory skin disease characterized
by hyperproliferation and abnormal differentiation of keratinocytes and infiltration of …

Psoriasis is a common, inflammatory autoimmune skin disease. Early detection of an IFN-1
signature occurs in many psoriasis lesions, but the source of IFN production remains …

Psoriasis is a common chronic inflammatory and immune‐mediated skin disease.
Antagonists of TNF‐α and, recently, IL‐17 have proven to be highly effective in the treatment …

Proinflammatory cytokine signaling in keratinocytes plays a crucial role in the pathogenesis
of psoriasis, a skin disease characterized by hyperproliferation and abnormal differentiation …

Psoriasis is a chronic inflammatory skin disease in which epidermal hyperplasia results from
skin infiltration by type IT lymphocytes and release of associated cytokines. A multifunctional …

Psoriasis is a common immune-mediated disease in European populations; it is
characterized by inflammation and altered epidermal differentiation leading to redness and …

Antagonists of IL‐17A and its receptor have proven to be highly effective in the treatment of
psoriasis. However, many of the underlying molecular mechanisms involved in the …

Psoriasis is an immune-mediated chronic inflammatory skin disease with a complex
etiology. The proinflammatory cytokine IL-17A is known to play key role in the pathogenesis …

IL-6 is a pleiotropic proinflammatory cytokine that is elevated in serum and skin lesions of
patients with psoriasis. Anti-IL-6 therapies, however, which are effective for rheumatoid …