[PDF][PDF] TCR+/BCR+ dual-expressing cells and their associated public BCR clonotype are not enriched in type 1 diabetes
Ahmed and colleagues recently described a novel hybrid lymphocyte expressing both a B
and T cell receptor, termed double expresser (DE) cells. DE cells in blood of type 1 diabetes …
and T cell receptor, termed double expresser (DE) cells. DE cells in blood of type 1 diabetes …
[PDF][PDF] A public BCR present in a unique dual-receptor-expressing lymphocyte from type 1 diabetes patients encodes a potent T cell autoantigen
T and B cells are the two known lineages of adaptive immune cells. Here, we describe a
previously unknown lymphocyte that is a dual expresser (DE) of TCR and BCR and key …
previously unknown lymphocyte that is a dual expresser (DE) of TCR and BCR and key …
[HTML][HTML] Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes
The adaptive immune repertoire plays a critical role in type 1 diabetes (T1D) pathogenesis.
However, efforts to characterize B cell and T cell receptor (TCR) profiles in T1D subjects …
However, efforts to characterize B cell and T cell receptor (TCR) profiles in T1D subjects …
Identification of an anergic BND cell–derived activated B cell population (BND2) in young-onset type 1 diabetes patients
ZC Stensland, CA Magera, H Broncucia… - Journal of Experimental …, 2023 - rupress.org
Recent evidence suggests a role for B cells in the pathogenesis of young-onset type 1
diabetes (T1D), wherein rapid progression occurs. However, little is known regarding the …
diabetes (T1D), wherein rapid progression occurs. However, little is known regarding the …
[PDF][PDF] β-Cell identity in type 2 diabetes: lost or found?
AE Butler, S Dhawan - Diabetes, 2015 - Citeseer
Type 2 diabetes (T2DM) is characterized by deficits of b-cell mass and function. The deficit in
b-cell mass in patients with T2DM is up to; 65% compared with those without diabetes (1) …
b-cell mass in patients with T2DM is up to; 65% compared with those without diabetes (1) …
Altered BCR signalling quality predisposes to autoimmune disease and a pre‐diabetic state
S Königsberger, J Prodöhl, D Stegner, V Weis… - The EMBO …, 2012 - embopress.org
The spleen tyrosine kinase family members Syk and Zap‐70 are pivotal signal transducers
downstream of antigen receptors and exhibit overlapping expression patterns at early …
downstream of antigen receptors and exhibit overlapping expression patterns at early …
High-throughput sequencing reveals restricted TCR Vβ usage and public TCRβ clonotypes among pancreatic lymph node memory CD4+ T cells and their involvement …
I Marrero, C Aguilera, DE Hamm, A Quinn… - Molecular immunology, 2016 - Elsevier
Islet-reactive memory CD4+ T cells are an essential feature of type 1 diabetes (T1D) as they
are involved in both spontaneous disease and in its recurrence after islet transplantation …
are involved in both spontaneous disease and in its recurrence after islet transplantation …
T cell repertoire diversity is decreased in type 1 diabetes patients
Y Tong, Z Li, H Zhang, L Xia, M Zhang… - Genomics …, 2016 - academic.oup.com
Type 1 diabetes mellitus (T1D) is an immune-mediated disease. The autoreactive T cells in
T1D patients attack and destroy their own pancreatic cells. In order to systematically …
T1D patients attack and destroy their own pancreatic cells. In order to systematically …
Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes
HA Abdelsamed, CC Zebley, H Nguyen… - Nature …, 2020 - nature.com
The pool of beta cell-specific CD8+ T cells in type 1 diabetes (T1D) sustains an autoreactive
potential despite having access to a constant source of antigen. To investigate the long-lived …
potential despite having access to a constant source of antigen. To investigate the long-lived …
Identical β cell-specific CD8+ T cell clonotypes typically reside in both peripheral blood lymphocyte and pancreatic islets
A major issue regarding T cell responses in autoimmunity is how the repertoire compares
between the periphery and target organ. In type 1 diabetes, the status of at-risk or diabetic …
between the periphery and target organ. In type 1 diabetes, the status of at-risk or diabetic …