Despite being the target of extensive research efforts due to the COVID-19 (coronavirus
disease 2019) pandemic, relatively little is known about the dynamics of severe acute …

Positive-strand RNA viruses subvert the cellular endomembrane system for the generation
of distinct compartments termed replication organelles (ROs) that harbor the site where viral …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the
COVID19 pandemic, is a highly pathogenic β-coronavirus. As other coronaviruses, SARS …

Abstract SARS-CoV-2, like other coronaviruses, builds a membrane-bound replication
organelle to enable RNA replication. The SARS-CoV-2 replication organelle is composed of …

A mechanistic understanding of the SARS-CoV-2 viral replication cycle is essential to
develop new therapies for the COVID-19 global health crisis. In this study, we show that the …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
COVID-19, so understanding its biology and infection mechanisms is critical to facing this …

The SARS-CoV-2 pandemic and its unprecedented global societal and economic disruptive
impact has marked the third zoonotic introduction of a highly pathogenic coronavirus into the …

As an enveloped virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
contains a membrane protein (M) that mediates viral release from cellular membranes …

The COVID‐2019 pandemic is the most severe acute public health threat of the twenty‐first
century. To properly address this crisis with both robust testing and novel treatments, we …

While SARS-CoV-2 continues to adapt for human infection and transmission, genetic
variation outside of the spike gene remains largely unexplored. This study investigates a …