OBJECTIVES: Anti-inflammatory effects of tranexamic acid and aprotinin, used to abate
perioperative blood loss, are reported and might be of substantial clinical relevance. The …

PURPOSE: Antifibrinolytics, used in cardiac surgery to abate postoperative blood loss, share
anti-inflammatory properties by suppression of pro-inflammatory D-dimer and plasmin …

Background In cardiopulmonary bypass (CPB) patients, fibrinolysis may enhance
postoperative inflammatory response. We aimed to determine whether an additional …

Cardiac surgery with cardiopulmonary bypass (CPB) is associated with the development of
a systemic inflammatory response that can often lead to dysfunction of major organs. The …

Cardiac surgery involving a cardiopulmonary bypass is associated with the activation of the
hemostatic/inflammatory system. This is caused by the contact of blood with large …

The systemic endotoxemia that occurs with the institution of cardiopulmonary bypass (CPB)
is a potent stimulus for the release of proinflammatory cytokines, including tumor necrosis …

OBJECTIVES: Aprotinin is a broad-spectrum serine protease inhibitor that has been shown
to attenuate the systemic inflammatory response in patients undergoing cardiac surgery with …

Cardiopulmonary bypass has been shown to activate various inflammatory cascades in the
body, resulting in pathophysiological changes that may affect patient outcome after cardiac …

Objective: To rule out the effect of high-dose aprotinin in respect to the balance of
proinflammatory and anti-inflammatory mediators induced by cardiopulmonary bypass …

The potential for strategies that inhibit the inflammatory response to improve outcome after
cardiac surgery is clear. Large-scale multicentre trials investigating the most promising …