Network abnormalities and interneuron dysfunction in Alzheimer disease

JJ Palop, L Mucke - Nature Reviews Neuroscience, 2016 - nature.com
The function of neural circuits and networks can be controlled, in part, by modulating the
synchrony of their components' activities. Network hypersynchrony and altered oscillatory …

Synaptic depression and aberrant excitatory network activity in Alzheimer's disease: two faces of the same coin?

JJ Palop, L Mucke - Neuromolecular medicine, 2010 - Springer
Neurodegenerative diseases, including Alzheimer's disease (AD), target specific and
functionally connected neuronal networks, raising the possibility that neurodegeneration …

Neuronal network oscillations in neurodegenerative diseases

V Nimmrich, A Draguhn, N Axmacher - Neuromolecular medicine, 2015 - Springer
Cognitive and behavioral acts go along with highly coordinated spatiotemporal activity
patterns in neuronal networks. Most of these patterns are synchronized by coherent …

Neurophysiological signatures in Alzheimer's disease are distinctly associated with TAU, amyloid-β accumulation, and cognitive decline

KG Ranasinghe, J Cha, L Iaccarino… - Science translational …, 2020 - science.org
Neural synchrony is intricately balanced in the normal resting brain but becomes altered in
Alzheimer's disease (AD). To determine the neurophysiological manifestations associated …

Neuronal network excitability in Alzheimer's disease: the puzzle of similar versus divergent roles of amyloid β and tau

SF Kazim, JH Seo, R Bianchi, CS Larson, A Sharma… - Eneuro, 2021 - eneuro.org
Alzheimer's disease (AD) is the most frequent neurodegenerative disorder that commonly
causes dementia in the elderly. Recent evidence indicates that network abnormalities …

[HTML][HTML] Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model

L Verret, EO Mann, GB Hang, AMI Barth, I Cobos, K Ho… - Cell, 2012 - cell.com
Alzheimer's disease (AD) results in cognitive decline and altered network activity, but the
mechanisms are unknown. We studied human amyloid precursor protein (hAPP) transgenic …

[HTML][HTML] Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer's disease

D Shah, W Gsell, J Wahis, ES Luckett, T Jamoulle… - Cell reports, 2022 - cell.com
Dysfunctions of network activity and functional connectivity (FC) represent early events in
Alzheimer's disease (AD), but the underlying mechanisms remain unclear. Astrocytes …

What happens with the circuit in Alzheimer's disease in mice and humans?

B Zott, MA Busche, RA Sperling… - Annual review of …, 2018 - annualreviews.org
A major mystery of many types of neurological and psychiatric disorders, such as
Alzheimer's disease (AD), remains the underlying, disease-specific neuronal damage …

Enhanced gamma activity and cross-frequency interaction of resting-state electroencephalographic oscillations in patients with Alzheimer's disease

J Wang, Y Fang, X Wang, H Yang, X Yu… - Frontiers in aging …, 2017 - frontiersin.org
Cognitive impairment, functional decline and behavioral symptoms that characterize
Alzheimer's disease (AD) are associated with perturbations of the neuronal network. The …

Theta and gamma oscillatory dynamics in mouse models of Alzheimer's disease: A path to prospective therapeutic intervention

SF Mehak, AB Shivakumar, S Kumari… - Neuroscience & …, 2022 - Elsevier
Understanding the neural basis of cognitive deficits, a key feature of Alzheimer's disease
(AD), is imperative for achieving the therapy of the disease. Rhythmic oscillatory activities in …