Our current understanding of the relationship between the dopaminergic system and human
brain disorders is based on two fundamental discoveries: dopamine-replacement herapy …

Because of their importance in pathophysiology, the dopamine receptors have been the
subjects of intense pharmacological and physiological research. Their structures have …

Although investigators in the mid 1980s were not aware of it at the time, efforts to affinity-
purify the hamster P,-adrenergic receptor (Benovic et al., 1984) would lead directly, several …

The application of modem molecular biological methods has had an increasing and
dramatic impact upon the discipline of molecular neuropharmacology. This is particularly …

The responses obtained with drugs that act at dopamine receptors depend on the spectrum
of receptors stimulated, the pattern of stimulation and the neuronal signal-transduction …

The catecholamine dopamine plays a role in the functioning of numerous vertebrate and
invertebrate organisms. In mammals, dopamine affects a diverse array of processes, such as …

Recent progress in understanding the molecular biology and pharmacology of dopamine
receptors in mammalian brain has been remarkable and can serve as a basis for …

For over a decade it has been generally assumed that all the pharmacological and
biochemical actions of dopamine within the central nervous system and periphery were …

The D 1/D 2 dopamine receptor classification is widely accepted. However, intense
investigative efforts over the last several years using pharmacological, biochemical and …

Our knowledge of dopamine receptor diversity has markedly increased during the past few
years as a result of discovery of five distinct genes and splice variants. These genes can be …