“Higher order” addiction molecular genetics: convergent data from genome-wide association in humans and mice
GR Uhl, T Drgon, C Johnson, OO Fatusin… - Biochemical …, 2008 - Elsevier
Family, adoption and twin data each support substantial heritability for addictions. Most of
this heritable influence is not substance-specific. The overlapping genetic vulnerability for …
this heritable influence is not substance-specific. The overlapping genetic vulnerability for …
Molecular genetics of addiction and related heritable phenotypes: genome‐wide association approaches identify “connectivity constellation” and drug target genes …
Genome‐wide association (GWA) can elucidate molecular genetic bases for human
individual differences in complex phenotypes that include vulnerability to addiction. Here …
individual differences in complex phenotypes that include vulnerability to addiction. Here …
Genome wide association for addiction: replicated results and comparisons of two analytic approaches
Background Vulnerabilities to dependence on addictive substances are substantially
heritable complex disorders whose underlying genetic architecture is likely to be polygenic …
heritable complex disorders whose underlying genetic architecture is likely to be polygenic …
Implications of genome wide association studies for addiction: are our a priori assumptions all wrong?
Substantial genetic contributions to addiction vulnerability are supported by data from twin
studies, linkage studies, candidate gene association studies and, more recently, Genome …
studies, linkage studies, candidate gene association studies and, more recently, Genome …
The genetics of addiction—a translational perspective
Addictions are serious and common psychiatric disorders, and are among the leading
contributors to preventable death. This selective review outlines and highlights the need for …
contributors to preventable death. This selective review outlines and highlights the need for …
Meta-analysis and genome-wide interpretation of genetic susceptibility to drug addiction
Background Classical genetic studies provide strong evidence for heritable contributions to
susceptibility to developing dependence on addictive substances. Candidate gene and …
susceptibility to developing dependence on addictive substances. Candidate gene and …
New insights into the genetics of addiction
MD Li, M Burmeister - Nature Reviews Genetics, 2009 - nature.com
Drug addiction is a common brain disorder that is extremely costly to the individual and to
society. Genetics contributes significantly to vulnerability to this disorder, but identification of …
society. Genetics contributes significantly to vulnerability to this disorder, but identification of …
Human genetics of addiction: new insights and future directions
DB Hancock, CA Markunas, LJ Bierut… - Current psychiatry …, 2018 - Springer
Abstract Purpose of Review With the advent of the genome-wide association study (GWAS),
our understanding of the genetics of addiction has made significant strides forward. Here …
our understanding of the genetics of addiction has made significant strides forward. Here …
The genetics, neurogenetics and pharmacogenetics of addiction
Addictions are prevalent psychiatric disorders that confer remarkable personal and social
burden. Despite substantial evidence for their moderate, yet robust, heritability (approx …
burden. Despite substantial evidence for their moderate, yet robust, heritability (approx …
Addiction genetics and pleiotropic effects of common haplotypes that make polygenic contributions to vulnerability to substance dependence
Abundant evidence from family, adoption, and twin studies point to large genetic
contributions to individual differences in vulnerability to develop dependence on one or …
contributions to individual differences in vulnerability to develop dependence on one or …
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