Development and challenges of antimicrobial peptides for therapeutic applications

CH Chen, TK Lu - Antibiotics, 2020 - mdpi.com
More than 3000 antimicrobial peptides (AMPs) have been discovered, seven of which have
been approved by the US Food and Drug Administration (FDA). Now commercialized, these …

Will new generations of modified antimicrobial peptides improve their potential as pharmaceuticals?

NK Brogden, KA Brogden - International journal of antimicrobial agents, 2011 - Elsevier
The concept of antimicrobial peptides (AMPs) as potent pharmaceuticals is firmly
established in the literature, and most research articles on this topic conclude by stating that …

Antimicrobial peptides as therapeutic agents: Opportunities and challenges

M Mahlapuu, C Björn, J Ekblom - Critical reviews in biotechnology, 2020 - Taylor & Francis
The rapid development of microbial resistance to conventional antibiotics has accelerated
efforts to find anti-infectives with a novel mode-of-action, which are less prone to bacterial …

Discovery, optimization, and clinical application of natural antimicrobial peptides

AA Rodríguez, A Otero-González, M Ghattas… - Biomedicines, 2021 - mdpi.com
Antimicrobial peptides (AMPs) are widespread in multicellular organisms. These structurally
diverse molecules are produced as the first line of defense against pathogens such as …

The therapeutic applications of antimicrobial peptides (AMPs): a patent review

HK Kang, C Kim, CH Seo, Y Park - Journal of microbiology, 2017 - Springer
Antimicrobial peptides (AMPs) are small molecules with a broad spectrum of antibiotic
activities against bacteria, yeasts, fungi, and viruses and cytotoxic activity on cancer cells, in …

Antimicrobial peptides—Mechanisms of action, antimicrobial effects and clinical applications

J Talapko, T Meštrović, M Juzbašić, M Tomas, S Erić… - Antibiotics, 2022 - mdpi.com
The growing emergence of antimicrobial resistance represents a global problem that not
only influences healthcare systems but also has grave implications for political and …

Characterization of antimicrobial peptides toward the development of novel antibiotics

W Aoki, M Ueda - Pharmaceuticals, 2013 - mdpi.com
Antimicrobial agents have eradicated many infectious diseases and significantly improved
our living environment. However, abuse of antimicrobial agents has accelerated the …

Antimicrobial peptides (AMPs): A promising class of antimicrobial compounds

M Erdem Büyükkiraz, Z Kesmen - Journal of applied …, 2022 - academic.oup.com
Antimicrobial peptides (AMPs) are compounds, which have inhibitory activity against
microorganisms. In the last decades, AMPs have become powerful alternative agents that …

Antimicrobial peptides: premises and promises

KVR Reddy, RD Yedery, C Aranha - International journal of antimicrobial …, 2004 - Elsevier
Antimicrobial peptides (AMPs) are an important component of the natural defences of most
living organisms against invading pathogens. These are relatively small (< 10kDa), cationic …

Antimicrobial peptides: current status and therapeutic potential

AR Koczulla, R Bals - Drugs, 2003 - Springer
Antimicrobial peptides (AMPs) are effector molecules of the innate immune system. A variety
of AMPs have been isolated from species of all kingdoms and are classified based on their …