With a cure rate of 80% in childhood acute lymphoblastic leukemia (ALL), great effort has
been expended to precisely define risk assessment so that intensive treatment is given to …

Quantification of residual leukemic cells at early time points during therapy can reliably
predict the outcome in children with acute lymphoblastic leukemia (ALL). Recently …

Acute lymphoblastic leukemia (ALL) in children has turned a mostly curable disease.
However, 10-20% of children still suffer from a leukemia relapse. To optimize and …

Improved laboratory techniques now allow a more sensitive detection of leukemia cells at
designated intervals throughout therapy. Using flow cytometry and polymerase chain …

Background Minimal residual disease (MRD) testing by higher performance techniques
such as flow cytometry and polymerase chain reaction (PCR) can be used to detect the …

The pace of disappearance of leukemic blasts in response to therapy has long been
recognized as the most important prognostic factor in childhood acute lymphoblastic …

Acute lymphoblastic leukemia (ALL) represents the most frequent malignancy in childhood.
Last decades brought enormous progress in ALL treatment and in the understanding of ALL …

Acute leukemia is the most common malignancy in children accounting for approximately
one-third of all childhood cancers. Modern treatment protocols lead to complete remission …

A certain quantity of residual leukemic cells at several time points during chemotherapy of
childhood acute lymphoblastic leukemia (ALL) was proved to predict outcome. Future …

In the last few decades, increasing therapy intensity has been the most important tool to
improve the survival of children with acute lymphoblastic leukemia (ALL)[1, 2]. Yet, we are …