The high mortality and widespread impact of malaria have resulted in this disease being the
strongest evolutionary selective force in recent human history, and genes that confer …

Malaria has been the pre-eminent cause of early mortality in many parts of the world
throughout much of the last five thousand years and, as a result, it is the strongest force for …

The term 'innate resistance'covers mechanisms of resistance that operate early in the course
of infections, preceding adaptive immune responses which exert effects after several days …

The haemoglobinopathies have a celebrated role in the study of human genetics as the first
examples of balanced polymorphisms described in human populations. Over the last 50 …

Background While many individual genes have been identified that confer protection against
malaria, the overall impact of host genetics on malarial risk remains unknown. Methods and …

Evolution results from natural selec tion, operating over a range of ge netic diversity that
arises from the mutation and recombination of genes. Variant genes that confer some …

The natural selection of genes influencing susceptibility to Plasmodium falciparum malaria is
briefly discussed. These include α-globin, β-globin, glucose-6-phosphate dehydrogenase …

The high mortality from malaria in sub-Sahara Africa selected multiple genes that give the
population a selective advantage. Identification of the genetic basis for resistance may …

Statistical power to detect disease variants can be increased by weighting candidates by
their evidence of natural selection. To demonstrate that this theoretical idea works in …

Malaria remains one of the most prevalent parasitoses worldwide. About 350 to 500million
febrile episodes are observed yearly in African children alone and more than 1million …