Leptin and insulin are secreted into the maternal and to a lesser extent into the fetal
bloodstream where they act as placental signals and nourish the fetus, making them …

Leptin is now considered an important signalling molecule of the reproductive system, as it
regulates the production of gonadotrophins, the blastocyst formation and implantation, the …

Control of processes responsible for food intake and regulation of energy homeostasis
during pregnancy is crucial for mother as well as for fetus development. Leptin is one of the …

Leptin, one of the adipokines that controls energy metabolism via the central nervous
system, also has pleiotropic peripheral effects, acting as a proinflammatory cytokine. Leptin …

Placenta is an important source of leptin during pregnancy that contributes to the high
plasma leptin levels in pregnant women. Leptin and its functional receptors are synthesized …

Leptin was initially identified as an adipocyte-derived hormone that decreases food intake
and body weight via its receptor in the hypothalamus. Subsequent animal studies revealed …

Type 1 diabetes mellitus (T1DM) is still associated with increased risk for severe maternal
and fetal complications but their pathomechanism remains unclear. We investigated into …

Leptin is a homeostatic regulator in the placenta where it promotes proliferation, protein
synthesis and the expression of tolerogenic maternal response molecules such as HLA-G …

Objective. Placenta plays a central role in fetal nutrition. During gestational diabetes mellitus
(GDM), it suffers structural and functional alterations which affect the health of both mother …

Leptin is an adipocytokine that is also synthesized by the placenta. Leptin and its receptor,
which is also expressed by the placenta, are believed to play an auto-and paracrine role in …