There is a well-defined regulatory framework governing the approval of chemicals for use as
pharmaceuticals or release into the environment. Toxicity assessment is thus a major hurdle …

The unfavorable effects of environmental pollutants are becoming increasingly evident. In
recent years, Caenorhabditis elegans (C. elegans) has been used as a powerful terrestrial …

Caenorhabditis elegans is a small nematode that can be maintained at low cost and
handled using standard in vitro techniques. Unlike toxicity testing using cell cultures, C …

Background: Modern toxicology is shifting from an observational to a mechanistic science.
As part of this shift, high-throughput toxicity assays are being developed using alternative …

Caenorhabditis elegans has been proven to be a useful model organism for investigating
molecular and cellular aspects of numerous human diseases. More recently, investigators …

Therapeutic drug development is a long, expensive, and complex process that usually takes
12–15 years. In the early phases of drug discovery, in particular, there is a growing need for …

Drug discovery and drug target identification are two intimately linked facets of intervention
strategies aimed at effectively combating pathological conditions in humans. Simple model …

A number of practical advantages have made the nematode Caenorhabditis elegans a
useful model for genetic and developmental biological research. These same advantages …

The nematode Caenorhabditis elegans has emerged as an important animal model in
various fields including neurobiology, developmental biology, and genetics. Characteristics …

This book focuses on exposure toxicology in C. elegans. The nematode Caenorhabditis
elegans is sensitive to various environmental toxicants and stresses, and has proven to be …