Acetaminophen (APAP), one of the most widely used antipyretic and analgesic drugs,
principally contributes to drug-induced liver injury when taken at a high dose. APAP-induced …

Acute liver failure caused by drug overdose is a significant clinical problem in developed
countries. Acetaminophen (APAP), a widely used analgesic and antipyretic drug, but its …

In many affluent nations, acetaminophen (APAP) overdose is the leading cause of drug-
induced acute liver failure. The process of APAP-induced liver injury (AILI) is intimately tied …

Acetaminophen (APAP) hepatotoxicity is an important cause of acute liver failure, resulting
in massive deaths in many developed countries. Currently, the metabolic process of APAP in …

Acetaminophen (AAP) overdose and the resulting hepatotoxicity is an important clinical
problem. In addition, AAP is widely used as a prototype hepatotoxin to study mechanisms of …

Simple Summary An injury to the liver caused by a drug or its metabolites is referred to as
drug-induced liver injury (DILI). The clinical manifestations of DILI are varied, and it may …

Acetaminophen (APAP) hepatotoxicity is currently the single most important cause of acute
liver failure in the US, and is associated with a significant number of deaths. The toxic …

Background Drug (eg, acetaminophen, APAP)-associated hepatotoxicity is the major cause
of acute liver failure. Emerging evidence shows that initial tissue damage caused by APAP …

Acetaminophen (APAP) hepatotoxicity because of overdose is the most frequent cause of
acute liver failure in the western world. Metabolic activation of APAP and protein adduct …

Neutrophils and macrophages infiltrate after acetaminophen (APAP)‐induced liver injury
starts to develop. However, their precise roles still remain elusive. In untreated and control …