Deficiency in the membrane cytoskeletal protein dystrophin is the underlying cause of the
progressive muscle wasting disease named Duchenne muscular dystrophy. In order to …

The diaphragm is a crucial muscle involved in active inspiration and whole body
homeostasis. Previous biochemical, immunochemical and cell biological investigations …

In skeletal muscle, the dystrophin-glycoprotein complex forms a membrane-associated
assembly of relatively low abundance, making its detailed proteomic characterization in …

Mdx mice with a spontaneous mutation in exon 23 of the Dmd gene represent the most
common model to investigate the pathophysiology of Duchenne muscular dystrophy (DMD) …

The progressive degeneration of the skeletal musculature in Duchenne muscular dystrophy
is accompanied by reactive myofibrosis, fat substitution, and chronic inflammation. Fibrotic …

Duchenne muscular dystrophy is an inherited disorder of early childhood that affects
multiple systems in the body. Besides late-onset cardio-respiratory syndrome and various …

Duchenne muscular dystrophy is a lethal genetic disease of childhood caused by primary
abnormalities in the gene coding for the membrane cytoskeletal protein dystrophin. The mdx …

The highly progressive neuromuscular disorder dystrophinopathy is triggered by primary
abnormalities in the Dmd gene, which causes cytoskeletal instability and loss of …

Introduction: Progressive skeletal muscle wasting is the manifesting symptom of Duchenne
muscular dystrophy, an X-linked inherited disorder triggered by primary abnormalities in the …

Duchenne muscular dystrophy is the most commonly inherited neuromuscular disorder in
humans. Although the primary genetic deficiency of dystrophin in X‐linked muscular …