The purpose of this study was to estimate the pharmacological effect of geniposide (GEN) on
depression, caused by chronic unpredictable mild stress (CUMS), and explore its potential …

The purpose of this study was to investigate the antidepressant mechanism of GEN
(geniposide) on depression mice induced by LPS. The mice were intragastrically treated …

We previously reported that penta-acetyl geniposide ((Ac) 5 GP, an acetylated derivative of
geniposide) exhibited better pharmacological functions than geniposide, a major active …

Major depression is a common long-lasting or recurrent psychiatric disease with high
lifetime prevalence and high incidence of suicide. The main purpose of the current study …

Geniposide as the major active component of Gardenia jasminoides Ellis has
neuroprotective activity. This study elucidated the potential antidepressant-like effect of …

Geniposide (GP), a bioactive iridoid glycoside isolated from Gardenia jasminoides Ellis, as
well as an agonist of Glucagon-like peptide-1 receptor (GLP-1R), has been reported to …

Background. Depression is a major cause of disability and most antidepressant medicines
are ineffective owing to their high toxicity and numerous adverse effects. As a result, there is …

Our previous studies have demonstrated that the total flavonoids (XBXT‐2) isolated from the
extract of Xiaobuxin‐Tang (XBXT), a traditional Chinese herbal decoction, ameliorated …

Background Depression is a severe mental disorder. Unfortunately, more than half of
patients with major depression disorder cannot achieve remission after initial treatment with …

Abstract Background Kai Xin San (KXS) was widely applied for the treatment of depression
for thousands of years. However, the underlying antidepressant mechanism of KXS remains …