Breast milk-derived human milk oligosaccharides promote Bifidobacterium interactions within a single ecosystem

MAE Lawson, IJ O'Neill, M Kujawska… - The ISME …, 2020 - academic.oup.com
Diet-microbe interactions play an important role in modulating the early-life microbiota, with
Bifidobacterium strains and species dominating the gut of breast-fed infants. Here, we …

Human milk oligosaccharide-sharing by a consortium of infant derived Bifidobacterium species

C Walsh, JA Lane, D van Sinderen, RM Hickey - Scientific Reports, 2022 - nature.com
Bifidobacteria are associated with a host of health benefits and are typically dominant in the
gut microbiota of healthy, breast-fed infants. A key adaptation, facilitating the establishment …

Infant microbiome cultivation and metagenomic analysis reveal Bifidobacterium 2'-fucosyllactose utilization can be facilitated by coexisting species

YC Lou, BE Rubin, MC Schoelmerich… - Nature …, 2023 - nature.com
The early-life gut microbiome development has long-term health impacts and can be
influenced by factors such as infant diet. Human milk oligosaccharides (HMOs), an essential …

Nursing our microbiota: molecular linkages between bifidobacteria and milk oligosaccharides

DA Sela, DA Mills - Trends in microbiology, 2010 - cell.com
As the sole nutrition provided to infants, bioactive molecules dissolved in milk influence the
development of our gut microbiota. Accordingly, human milk oligosaccharides (HMOs) are …

Bifidobacterial utilization of human milk oligosaccharides

DA Sela - International journal of food microbiology, 2011 - Elsevier
A promising strategy to improve health is the rational manipulation of one's beneficial
microbiota via dietary interventions. This is observed in nature where specific bifidobacteria …

Human milk oligosaccharides and infant gut bifidobacteria: Molecular strategies for their utilization

P Thomson, DA Medina, D Garrido - Food Microbiology, 2018 - Elsevier
Breast milk is the gold standard in infant nutrition. In addition to provide essential nutrients
for the newborn, it contains multiple bioactive molecules that provide protection and …

Varied Pathways of Infant Gut-Associated Bifidobacterium to Assimilate Human Milk Oligosaccharides: Prevalence of the Gene Set and Its Correlation with …

M Sakanaka, A Gotoh, K Yoshida, T Odamaki… - Nutrients, 2019 - mdpi.com
The infant's gut microbiome is generally rich in the Bifidobacterium genus. The mother's milk
contains natural prebiotics, called human milk oligosaccharides (HMOs), as the third most …

Comparative transcriptomics reveals key differences in the response to milk oligosaccharides of infant gut-associated bifidobacteria

D Garrido, S Ruiz-Moyano, DG Lemay, DA Sela… - Scientific reports, 2015 - nature.com
Breast milk enhances the predominance of Bifidobacterium species in the infant gut,
probably due to its large concentration of human milk oligosaccharides (HMO). Here we …

Maternal fucosyltransferase 2 status affects the gut bifidobacterial communities of breastfed infants

ZT Lewis, SM Totten, JT Smilowitz, M Popovic, E Parker… - Microbiome, 2015 - Springer
Background Individuals with inactive alleles of the fucosyltransferase 2 gene (FUT2; termed
the 'secretor'gene) are common in many populations. Some members of the genus …

A novel gene cluster allows preferential utilization of fucosylated milk oligosaccharides in Bifidobacterium longum subsp. longum SC596

D Garrido, S Ruiz-Moyano, N Kirmiz, JC Davis… - Scientific reports, 2016 - nature.com
The infant intestinal microbiota is often colonized by two subspecies of Bifidobacterium
longum: subsp. infantis (B. infantis) and subsp. longum (B. longum). Competitive growth of B …