Methionine and Leucine Promote mTOR Gene Transcription and Milk Synthesis in Mammary Epithelial Cells through the eEF1Bα-UBR5-ARID1A Signaling

H Qi, M Yu, X Fan, Y Zhou, M Zhang… - Journal of Agricultural …, 2024 - ACS Publications
Amino acids are essential for the activation of the mechanistic target of rapamycin (mTOR),
but the corresponding molecular mechanism is not yet fully understood. We previously found …

Methionine and leucine induce ARID1A degradation to promote mTOR expression and milk synthesis in mammary epithelial cells

H Qi, L Wang, M Zhang, Z Wang, X Gao, M Li - The Journal of Nutritional …, 2022 - Elsevier
Amino acids can activate mTOR to promote milk synthesis in mammary epithelial cells
(MECs), but the underlying molecular mechanism is still largely unknown. The objective is to …

Met stimulates ARID1A degradation and activation of the PI3K-SREBP1 signaling to promote milk fat synthesis in bovine mammary epithelial cells

H Qi, G Lin, S Guo, X Guo, C Yu, M Zhang… - Animal …, 2023 - Taylor & Francis
Methionine (Met) can promote milk fat synthesis in bovine mammary epithelial cells
(BMECs), but the potential molecular mechanism is largely unknown. In this report, we aim …

ARID1B blocks methionine-stimulated mTOR activation to inhibit milk fat and protein synthesis in and proliferation of mouse mammary epithelial cells

G Lin, H Qi, X Guo, W Wang, M Zhang, X Gao - The Journal of Nutritional …, 2023 - Elsevier
Met can function through the mTOR signaling pathway, but the molecular mechanism is not
fully understood. Here we investigated the role of ARID1B in this regulatory process …

METTL3 is a key regulator of milk synthesis in mammary epithelial cells

L Wang, H Qi, D Li, L Liu, D Chen… - Cell Biology …, 2022 - Wiley Online Library
The enzyme m6A methyltransferase‐like 3 (METTL3) catalyzes N6‐methyladenosine (m6A)
modification in eukaryotic messenger RNAs (mRNAs). However, the physiological function …

[HTML][HTML] Enhanced supply of methionine or arginine alters mechanistic target of rapamycin signaling proteins, messenger RNA, and microRNA abundance in heat …

AAK Salama, M Duque, L Wang, K Shahzad… - Journal of dairy …, 2019 - Elsevier
Heat stress (HS) causes reductions in milk production, but it is unclear whether this effect is
due to reduced number or functional capacity (or both) of mammary cells. Methionine …

Methionine Promotes Milk Synthesis through the BRCC36-BRG1-mTOR Signaling Axis in Mammary Epithelial Cells

L Xie, R Li, J Zhang, H Li, X Gao… - Journal of Agricultural …, 2024 - ACS Publications
Methionine (Met) functions as a key stimulator on the mTOR signaling pathway and milk
synthesis, but the molecular mechanism remains incompletely understood. We investigated …

GlyRS is a new mediator of amino acid‐induced milk synthesis in bovine mammary epithelial cells

C Luo, H Qi, X Huang, M Li, L Zhang… - Journal of Cellular …, 2019 - Wiley Online Library
Amino acids are required for the mammalian target of rapamycin (mTOR) signaling pathway
and milk synthesis in bovine mammary epithelial cells (BMECs). However, the mechanism …

Isoleucine stimulates mTOR and SREBP-1c gene expression for milk synthesis in mammary epithelial cells through BRG1-mediated chromatin remodelling

Q Hao, Z Wang, L Wang, M Han, M Zhang… - British Journal of …, 2023 - cambridge.org
Several amino acids can stimulate milk synthesis in mammary epithelial cells (MEC);
however, the regulatory role of isoleucine (Ile) and underlying molecular mechanism remain …

[HTML][HTML] Increased milk protein synthesis in response to exogenous growth hormone is associated with changes in mechanistic (mammalian) target of rapamycin …

Q Sciascia, D Pacheco, SA McCoard - Journal of dairy science, 2013 - Elsevier
The objective of this study was to determine if increased milk protein synthesis observed in
lactating dairy cows treated with growth hormone (GH) was associated with mechanistic (or …