Rationale Dopamine is strongly implicated in the ability to shift behavior in response to
changing stimulus-reward contingencies. Objectives We investigated the effects of systemic …

Dopamine plays a role in generating flexible adaptive responses in changing environments.
Chronic administration of D2-like agonist quinpirole (QNP) induces behavioral sensitization …

Rationale Dopamine D2-like receptors (D2R) are important drug targets in schizophrenia
and Parkinson's disease, but D2R ligands also cause cognitive inflexibility such as poor …

While self-administration and place conditioning studies have shown that dopamine D2-like
receptor agonists produce reward-related learning, the effects of dopamine D1-like receptor …

Impaired cognitive flexibility in visual reversal-learning tasks has been observed in a wide
range of neurological and neuropsychiatric disorders. Although both human and animal …

Converging evidence supports a role for mesocorticolimbic dopaminergic systems in a
subject's ability to shift behavior in response to changing stimulus-reward contingencies. To …

Rationale The prediction error hypothesis of dopamine action states that dopamine signals
are necessary for the brain to update the predictive significance of cues. Yet, little is known …

Individual variability in reward-based learning has been ascribed to quantitative variation in
baseline levels of striatal dopamine. However, direct evidence for this pervasive hypothesis …

Dopamine is critical for directing goal-oriented behavior. We investigated dopamine D 2
receptor involvement in reversal learning and reinforcement efficacy in mice lacking …

Dopamine D1/D5 receptor agonists may enhance cognition by mimicking dopamine's
neurophysiological actions on the processes underlying learning and memory. The present …