Human NK cells display important antifungal activity against Aspergillus fumigatus, which is directly mediated by IFN-γ release

M Bouzani, M Ok, A McCormick, F Ebel… - The Journal of …, 2011 - journals.aai.org
Despite the strong interest in the NK cell-mediated immunity toward malignant cells and
viruses, there is a relative lack of data on the interplay between NK cells and filamentous …

[HTML][HTML] Natural killer cells in antifungal immunity

S Schmidt, L Tramsen, T Lehrnbecher - Frontiers in immunology, 2017 - frontiersin.org
Invasive fungal infections are still an important cause of morbidity and mortality in
immunocompromised patients such as patients suffering from hematological malignancies …

Early NK cell-derived IFN-γ is essential to host defense in neutropenic invasive aspergillosis

SJ Park, MA Hughes, M Burdick… - The Journal of …, 2009 - journals.aai.org
Invasive aspergillosis is among the most common human fungal infections and occurs in
patients with severe and complex defects in immune responses. NK cells have previously …

Natural killer cells and antifungal host response

S Schmidt, SY Zimmermann, L Tramsen… - Clinical and Vaccine …, 2013 - Am Soc Microbiol
As a result of improved experimental methodologies and a better understanding of the
immune system, there is increasing insight into the antifungal activity of natural killer (NK) …

Human Natural Killer Cells Exhibit Direct Activity Against Aspergillus fumigatus Hyphae, But Not Against Resting Conidia

S Schmidt, L Tramsen, M Hanisch… - Journal of Infectious …, 2011 - academic.oup.com
Because natural killer (NK) cells kill tumor cells and combat infections, there is growing
interest in adoptively transferring NK cells to hematopoietic stem cell recipients …

Human Natural Killer Cells Acting as Phagocytes Against Candida albicans and Mounting an Inflammatory Response That Modulates Neutrophil Antifungal Activity

J Voigt, K Hünniger, M Bouzani… - The Journal of …, 2014 - academic.oup.com
Background. Natural killer (NK) cells are innate lymphocytes with potent cytotoxic activity.
Whereas activity of NK cells has been demonstrated against the fungal pathogens …

Phenotypic and functional characterization of NK cells in human immune response against the dimorphic fungus Paracoccidioides brasiliensis

LNA Longhi, RM da Silva, MC Fornazim… - The Journal of …, 2012 - journals.aai.org
Besides their role in fighting viral infection and tumor resistance, recent studies have shown
that NK cells also participate in the immune response against other infectious diseases. The …

[HTML][HTML] CD56 is a pathogen recognition receptor on human natural killer cells

S Ziegler, E Weiss, AL Schmitt, J Schlegel, A Burgert… - Scientific reports, 2017 - nature.com
Aspergillus (A.) fumigatus is an opportunistic fungal mold inducing invasive aspergillosis (IA)
in immunocompromised patients. Although antifungal activity of human natural killer (NK) …

Interleukin-12 Enhances Antifungal Activity of Human Mononuclear Phagocytes against Aspergillus fumigatus: Implications for a Gamma Interferon-Independent …

E Roilides, S Tsaparidou, I Kadiltsoglou… - Infection and …, 1999 - Am Soc Microbiol
The potential of recombinant human interleukin-12 (IL-12) to enhance the capacity of human
monocytes (MNC) to elicit an oxidative burst and damage hyphae of Aspergillus fumigatus …

Differential role of NK cells against Candida albicans infection in immunocompetent or immunocompromised mice

J Quintin, J Voigt, R van der Voort… - European journal of …, 2014 - Wiley Online Library
Little is known regarding the role of NK cells during primary and secondary disseminated
Candida albicans infection. We assessed the role of NK cells for host defense against …