Phase 2 ventricular arrhythmias in acute myocardial infarction: a neglected target for therapeutic antiarrhythmic drug development and for safety pharmacology …

H Clements‐Jewery, DJ Hearse… - British journal of …, 2005 - Wiley Online Library
Ventricular fibrillation (VF), a cause of sudden cardiac death (SCD) in the setting of acute
myocardial infarction (MI), remains a major therapeutic challenge. In humans, VF may occur …

Ventricular arrhythmias in first acute myocardial infarction: epidemiology, mechanisms, and interventions in large animal models

SM Sattler, L Skibsbye, D Linz… - Frontiers in …, 2019 - frontiersin.org
Ventricular arrhythmia and subsequent sudden cardiac death (SCD) due to acute
myocardial infarction (AMI) is one of the most frequent causes of death in humans. Lethal …

Incidence and prognosis of early primary ventricular fibrillation in acute myocardial infarction—results of the Gruppo Italiano per lo Studio della Sopravvivenza nell' …

A Volpi, A Cavalli, L Santoro, E Negri… - The American journal of …, 1998 - Elsevier
Primary ventricular fibrillation (VF) complicating acute myocardial infarction (MI) predicts
short-term mortality. The broad category of patients with primary VF might include subgroups …

Ventricular arrhythmias in acute coronary syndromes—mechanisms and management

DE Thomas, N Jex, AR Thornley - Continuing Cardiology …, 2017 - Wiley Online Library
Ventricular arrhythmias occur commonly following myocardial infarction and carry important
prognostic implications. The mechanisms involved are varied and time‐dependent …

Ischemic ventricular arrhythmias: experimental models and their clinical relevance

JM Di Diego, C Antzelevitch - Heart rhythm, 2011 - Elsevier
In the United States, sudden cardiac death accounts for an estimated 300,000 to 350,000
cases each year, with 80,000 presenting as the first manifestation of a preexisting …

Rat models of ventricular fibrillation following acute myocardial infarction

LA Hundahl, J Tfelt-Hansen… - Journal of …, 2017 - journals.sagepub.com
A number of animal models have been designed in order to unravel the underlying
mechanisms of acute ischemia-induced arrhythmias and to test compounds and …

Treatment and prophylaxis of ventricular arrhythmias in acute myocardial infarction

RWF Campbell - The American Journal of Cardiology, 1983 - Elsevier
Remarkable advances have been made in the management of cardiac disease in the last 20
years, but antiarrhythmic drug strategy in the acute phase of myocardial infarction remains …

[HTML][HTML] Ventricular arrhythmia after acute myocardial infarction:'the perfect storm'

J Bhar-Amato, W Davies, S Agarwal - … & electrophysiology review, 2017 - ncbi.nlm.nih.gov
Ventricular tachyarrhythmias (VAs) commonly occur early in ischaemia, and remain a
common cause of sudden death in acute MI. The thrombolysis and primary percutaneous …

When is drug therapy warranted to prevent sudden cardiac death?

BN Singh - Drugs, 1991 - Springer
Sudden arrhythmic death is an important contributor to the mortality rate in patients with
cardiac disease, accounting for over 450 000 deaths per year in the USA alone. About 80 …

Basic electrophysiologic mechanisms of sudden cardiac death caused by acute myocardial ischemia and infarction

AL Wit - Cardiac electrophysiology clinics, 2017 - cardiacep.theclinics.com
Sudden cardiac death has traditionally been defined as “the unexpected natural death from
a cardiac cause within a short period, usually 1 hour from the onset of symptoms in a person …