Glioblastoma is an aggressive brain cancer with a very poor prognosis in which less than
6% of patients survive more than five-year post-diagnosis. The outcome of this disease for …

Tumor associated microvascular angiogenesis is an important biomarker for cancer
diagnostics. However, ultrasound is challenged in the detection of these microvascular …

Background Non-invasive high-resolution imaging of the cerebral vascular anatomy and
function is key for the study of intracranial aneurysms, stenosis, arteriovenous …

Rationale: Structure and function of the microvasculature provides critical information about
disease state, can be used to identify local regions of pathology, and has been shown to be …

Ultrasound localization microscopy can image microvasculature in vivo without sacrificing
imaging penetration depth. However, the reliance on super-resolution inference limits the …

Angiogenesis has been known as a hallmark of solid tumor cancers for decades, yet
ultrasound has been limited in its ability to detect the microvascular changes associated with …

Technologies to visualize whole organs across scales in vivo are essential for our
understanding of biology in health and disease. To date, only post-mortem techniques …

Abstract 4D ultrasound microvascular imaging was demonstrated by applying ultrafast
Doppler tomography (UFD-T) to the imaging of brain hemodynamics in rodents. In vivo real …

Increasing evidence has suggested a link between cerebrovascular disease and the
cognitive impairment associated with Alzheimer's disease. However, detailed descriptions of …

Super-resolution imaging methods promote tissue characterization beyond the spatial
resolution limits of the devices and bridge the gap between histopathological analysis and …