Association of loneliness with 10-year dementia risk and early markers of vulnerability for neurocognitive decline

J Salinas, AS Beiser, JK Samra, A O'Donnell… - Neurology, 2022 - AAN Enterprises
Background and Objectives Loneliness is common, and its prevalence is rising. The
relationship of loneliness with subsequent dementia and the early preclinical course of …

Loneliness and risk of all-cause, Alzheimer's, vascular, and frontotemporal dementia: a prospective study of 492,322 individuals over 15 years

AR Sutin, M Luchetti, D Aschwanden, X Zhu… - International …, 2023 - cambridge.org
Objectives: This study examined the association between loneliness and risk of incident all-
cause dementia and whether the association extends to specific causes of dementia …

Loneliness and risk of Alzheimer disease

RS Wilson, KR Krueger, SE Arnold… - Archives of general …, 2007 - jamanetwork.com
Context Social isolation in old age has been associated with risk of developing dementia,
but the risk associated with perceived isolation, or loneliness, is not well understood …

Loneliness and cognitive function in older adults without dementia: A systematic review and meta-analysis

KD Harrington, S Vasan, MJ Sliwinski… - Journal of Alzheimer's …, 2023 - content.iospress.com
Background: Loneliness has been highlighted as a risk factor for dementia. However, the
nature of the relationship between loneliness and cognitive function prior to onset of …

Feelings of loneliness, but not social isolation, predict dementia onset: results from the Amsterdam Study of the Elderly (AMSTEL)

TJ Holwerda, DJH Deeg, ATF Beekman… - Journal of Neurology …, 2014 - jnnp.bmj.com
Background Known risk factors for Alzheimer9s disease and other dementias include
medical conditions, genetic vulnerability, depression, demographic factors and mild …

Loneliness increases the risk of all-cause dementia and Alzheimer's disease

A Sundström, AN Adolfsson, M Nordin… - The Journals of …, 2020 - academic.oup.com
Objectives To examine the effect of perceived loneliness on the development of dementia
(all-cause), Alzheimer´ s disease (AD), and vascular dementia (VaD). Method The study …

Associations of loneliness with risk of Alzheimer's disease dementia in the Framingham Heart Study

SC Akhter‐Khan, Q Tao, TFA Ang… - Alzheimer's & …, 2021 - Wiley Online Library
Introduction The relationship between persistent loneliness and Alzheimer's disease (AD) is
unclear. We examined the relationship between different types of mid‐life loneliness and the …

[HTML][HTML] Loneliness, not social support, is associated with cognitive decline and dementia across two longitudinal population-based cohorts

R Freak-Poli, N Wagemaker, R Wang… - Journal of …, 2022 - content.iospress.com
Background: Poor social health is likely associated with cognitive decline and risk of
dementia; however, studies show inconsistent results. Additionally, few studies separate …

Loneliness and risk of dementia

AR Sutin, Y Stephan, M Luchetti… - The Journals of …, 2020 - academic.oup.com
Objective The present study tests whether loneliness is associated with risk of dementia in
the largest sample to date and further examines whether the association is independent of …

Association of higher cortical amyloid burden with loneliness in cognitively normal older adults

NJ Donovan, OI Okereke, P Vannini… - JAMA …, 2016 - jamanetwork.com
Importance Emotional and behavioral symptoms in cognitively normal older people may be
direct manifestations of Alzheimer disease (AD) pathophysiology at the preclinical stage …