High-throughput anatomic data can stimulate and constrain new hypotheses about how
neural circuits change in response to experience. Here, we use fluorescence-based …

Neocortical circuits can be altered by sensory and motor experience, with experimental
evidence supporting both anatomical and electrophysiological changes in synaptic …

Pyramidal neurons in layers 2/3 and 5 of primary somatosensory cortex (S1) exhibit
somewhat modest synaptic plasticity after whisker input deprivation. Whether neurons …

Synapses in the brain are continuously modified by experience, but the mechanisms are
poorly understood. In vitro and theoretical studies suggest threshold-lowering interactions …

The induction of synaptic plasticity at an individual dendritic glutamatergic spine can affect
neighboring spines. This local modulation generates dendritic plasticity microdomains …

Highlights•Different neuron types solve different learning/developmental problems.•Different
neuron types exhibit different dendritic and somatic input–output functions.•A diverse set of …

The organization of sensory maps in the cerebral cortex depends on experience, which
drives homeostatic and long-term synaptic plasticity of cortico-cortical circuits. In the mouse …

Experience-dependent plasticity (EDP) is essential for anatomical and functional maturation
of sensory circuits during development. Although the principal synaptic and circuit …

The distribution of synapses across dendritic arbors determines their contribution to neural
computations since nonlinear conductances amplify co-active clustered inputs. To determine …

Coordinated long-term plasticity of nearby excitatory synaptic inputs has been proposed to
shape experience-related neuronal information processing. To elucidate the induction rules …