Genetics of Congenital Heart Disease

Y Zhao, W Deng, Z Wang, Y Wang, H Zheng, K Zhou… - Clinica Chimica …, 2023 - Elsevier
During embryonic development, the cardiovascular system and the central nervous system
exhibit a coordinated developmental process through intricate interactions. Congenital heart …

[HTML][HTML] Biological and structural phenotypes associated with neurodevelopmental outcomes in congenital heart disease

CE Verrall, S Patel, L Travitz, J Tchieu… - Translational …, 2023 - ncbi.nlm.nih.gov
Neurodevelopmental disability (NDD) is recognised as one of the most common
comorbidities in children with congenital heart disease (CHD) and is associated with altered …

Congenital heart disease: the crossroads of genetics, epigenetics and environment

C Vecoli, S Pulignani, I Foffa… - Current …, 2014 - ingentaconnect.com
Congenital heart diseases (CHDs) are recognized as the most common type of birth
malformations. Although recent advances in pre-and neonatal diagnosis as well as in …

[HTML][HTML] Genetics of congenital heart disease: the contribution of the noncoding regulatory genome

AV Postma, CR Bezzina, VM Christoffels - Journal of human genetics, 2016 - nature.com
Congenital heart disease (CHD) is the most common type of birth defect. The advent of
corrective cardiac surgery and the increase in knowledge concerning the longitudinal care …

Genetic burden and associations with adverse neurodevelopment in neonates with congenital heart disease

GM Blue, E Ip, K Walker, EP Kirk… - American heart …, 2018 - Elsevier
Background Up to 20% of children with congenital heart disease (CHD) undergoing cardiac
surgery develop neurodevelopmental disabilities (NDD), with some studies reporting …

Genetic contribution to congenital heart disease (CHD)

NA Shabana, SU Shahid, U Irfan - Pediatric cardiology, 2020 - Springer
Congenital heart defects (CHD) are the most common congenital problems in neonates. The
basis for CHD is multifactorial, involving genetic and environmental components. The …

Genetics and genomics of congenital heart disease

S Zaidi, M Brueckner - Circulation research, 2017 - Am Heart Assoc
Congenital heart disease is the most common birth defect, and because of major advances
in medical and surgical management, there are now more adults living with congenital heart …

Molecular mechanisms of congenital heart disease

H Jing-bin, L Ying-long, S Pei-wu, L Xiao-dong… - Cardiovascular …, 2010 - Elsevier
BACKGROUND: Congenital heart disease (CHD) is the most common type of birth defect.
Despite the many advances in our understanding of cardiac development and many genes …

An update on the molecular diagnosis of congenital heart disease: focus on loss-of-function mutations

YJ Li, YQ Yang - Expert Review of Molecular Diagnostics, 2017 - Taylor & Francis
Introduction: Congenital heart disease (CHD) is the most common birth defect in humans. In
spite of tremendous advance in medical care, CHD is still a major contributor to substantial …

Congenital heart disease and genetic syndromes: new insights into molecular mechanisms

G Calcagni, M Unolt, MC Digilio, A Baban… - Expert review of …, 2017 - Taylor & Francis
Introduction: Advances in genetics allowed a better definition of the role of specific genetic
background in the etiology of syndromic congenital heart defects (CHDs). The identification …