The emerging role of branched-chain amino acids in liver diseases
EKK Lo, Felicianna, JH Xu, Q Zhan, Z Zeng… - Biomedicines, 2022 - mdpi.com
Chronic liver diseases pose a substantial health burden worldwide, with approximately two
million deaths each year. Branched-chain amino acids (BCAAs)—valine, leucine, and …
million deaths each year. Branched-chain amino acids (BCAAs)—valine, leucine, and …
Branched chain amino acids: beyond nutrition metabolism
Branched chain amino acids (BCAAs), including leucine (Leu), isoleucine (Ile), and valine
(Val), play critical roles in the regulation of energy homeostasis, nutrition metabolism, gut …
(Val), play critical roles in the regulation of energy homeostasis, nutrition metabolism, gut …
The branched‐chain amino acids valine and leucine have differential effects on hepatic lipid metabolism
CA Bishop, MB Schulze, S Klaus… - The FASEB …, 2020 - Wiley Online Library
Dairy intake, as a source of branched‐chain amino acids (BCAA), has been linked to a lower
incidence of type‐2‐diabetes and increased circulating odd‐chain fatty acids (OCFA). To …
incidence of type‐2‐diabetes and increased circulating odd‐chain fatty acids (OCFA). To …
[HTML][HTML] Branched-chain amino acids prevent hepatic fibrosis and development of hepatocellular carcinoma in a non-alcoholic steatohepatitis mouse model
K Takegoshi, M Honda, H Okada, R Takabatake… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Oral supplementation with branched-chain amino acids (BCAA; leucine, isoleucine, and
valine) in patients with liver cirrhosis potentially suppresses the incidence of hepatocellular …
valine) in patients with liver cirrhosis potentially suppresses the incidence of hepatocellular …
Use of branched-chain amino acids as a potential treatment for improving nutrition-related outcomes in advanced chronic liver disease
S Colosimo, S Bertoli, F Saffioti - Nutrients, 2023 - mdpi.com
Advanced chronic liver disease (ACLD) represents a complex and multifactorial clinical
entity characterized by liver dysfunction and associated complications. In recent years, the …
entity characterized by liver dysfunction and associated complications. In recent years, the …
Recent progress on branched-chain amino acids in obesity, diabetes, and beyond
MAB Siddik, AC Shin - Endocrinology and Metabolism, 2019 - synapse.koreamed.org
Branched-chain amino acids (BCAAs) are essential amino acids that are not synthesized in
our body; thus, they need to be obtained from food. They have shown to provide many …
our body; thus, they need to be obtained from food. They have shown to provide many …
Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease
AD Lake, P Novak, P Shipkova, N Aranibar… - Amino acids, 2015 - Springer
Nonalcoholic fatty liver disease (NAFLD) is a globally widespread disease of increasing
clinical significance. The pathological progression of the disease from simple steatosis to …
clinical significance. The pathological progression of the disease from simple steatosis to …
Supplementation of branched-chain amino acids decreases fat accumulation in the liver through intestinal microbiota-mediated production of acetic acid
M Iwao, K Gotoh, M Arakawa, M Endo, K Honda… - Scientific Reports, 2020 - nature.com
Non-alcoholic fatty liver disease (NAFLD) is a significant problem because its prevalence is
increasing worldwide. Recent animal studies have identified gut microbiota as a potentially …
increasing worldwide. Recent animal studies have identified gut microbiota as a potentially …
Branch chain amino acids: biomarkers of health and disease
BC Batch, K Hyland, LP Svetkey - Current Opinion in Clinical …, 2014 - journals.lww.com
Current evidence supports the potential use of BCAAs as biomarkers of disease. However,
questions regarding the mechanisms underlying the relationship of BCAAs to disease …
questions regarding the mechanisms underlying the relationship of BCAAs to disease …
Emerging roles of branched‐chain amino acid supplementation in human diseases
The branched‐chain amino acids (BCAAs), namely, valine, leucine, and isoleucine, are
indispensable amino acids required for body protein synthesis. Unlike other amino acids …
indispensable amino acids required for body protein synthesis. Unlike other amino acids …