The emerging role of branched-chain amino acids in liver diseases

EKK Lo, Felicianna, JH Xu, Q Zhan, Z Zeng… - Biomedicines, 2022 - mdpi.com
Chronic liver diseases pose a substantial health burden worldwide, with approximately two
million deaths each year. Branched-chain amino acids (BCAAs)—valine, leucine, and …

Branched chain amino acids: beyond nutrition metabolism

C Nie, T He, W Zhang, G Zhang, X Ma - International journal of molecular …, 2018 - mdpi.com
Branched chain amino acids (BCAAs), including leucine (Leu), isoleucine (Ile), and valine
(Val), play critical roles in the regulation of energy homeostasis, nutrition metabolism, gut …

The branched‐chain amino acids valine and leucine have differential effects on hepatic lipid metabolism

CA Bishop, MB Schulze, S Klaus… - The FASEB …, 2020 - Wiley Online Library
Dairy intake, as a source of branched‐chain amino acids (BCAA), has been linked to a lower
incidence of type‐2‐diabetes and increased circulating odd‐chain fatty acids (OCFA). To …

[HTML][HTML] Branched-chain amino acids prevent hepatic fibrosis and development of hepatocellular carcinoma in a non-alcoholic steatohepatitis mouse model

K Takegoshi, M Honda, H Okada, R Takabatake… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Oral supplementation with branched-chain amino acids (BCAA; leucine, isoleucine, and
valine) in patients with liver cirrhosis potentially suppresses the incidence of hepatocellular …

Use of branched-chain amino acids as a potential treatment for improving nutrition-related outcomes in advanced chronic liver disease

S Colosimo, S Bertoli, F Saffioti - Nutrients, 2023 - mdpi.com
Advanced chronic liver disease (ACLD) represents a complex and multifactorial clinical
entity characterized by liver dysfunction and associated complications. In recent years, the …

Recent progress on branched-chain amino acids in obesity, diabetes, and beyond

MAB Siddik, AC Shin - Endocrinology and Metabolism, 2019 - synapse.koreamed.org
Branched-chain amino acids (BCAAs) are essential amino acids that are not synthesized in
our body; thus, they need to be obtained from food. They have shown to provide many …

Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease

AD Lake, P Novak, P Shipkova, N Aranibar… - Amino acids, 2015 - Springer
Nonalcoholic fatty liver disease (NAFLD) is a globally widespread disease of increasing
clinical significance. The pathological progression of the disease from simple steatosis to …

Supplementation of branched-chain amino acids decreases fat accumulation in the liver through intestinal microbiota-mediated production of acetic acid

M Iwao, K Gotoh, M Arakawa, M Endo, K Honda… - Scientific Reports, 2020 - nature.com
Non-alcoholic fatty liver disease (NAFLD) is a significant problem because its prevalence is
increasing worldwide. Recent animal studies have identified gut microbiota as a potentially …

Branch chain amino acids: biomarkers of health and disease

BC Batch, K Hyland, LP Svetkey - Current Opinion in Clinical …, 2014 - journals.lww.com
Current evidence supports the potential use of BCAAs as biomarkers of disease. However,
questions regarding the mechanisms underlying the relationship of BCAAs to disease …

Emerging roles of branched‐chain amino acid supplementation in human diseases

N Tamanna, N Mahmood - International scholarly research …, 2014 - Wiley Online Library
The branched‐chain amino acids (BCAAs), namely, valine, leucine, and isoleucine, are
indispensable amino acids required for body protein synthesis. Unlike other amino acids …