With the knowledge that the receptors of sialic acid are overexpressed on the surface of
tumor-associated macrophages (TAMs), which play a crucial role in the tumor's progression …

Neutrophils and monocytes (N/Ms) are potential candidates for the delivery of therapeutic
agents to the tumor microenvironment (TME) because of their tumor-accumulating nature. L …

Polysialic acid (PSA) is a nonimmunogenic and biodegradable polysaccharide. In recent
years, PSA has shown its potential applications to cancer treatment. In this study, PSA …

Tumor-associated macrophages (TAMs) in the tumor microenvironment potentially enhance
tumor growth and invasion through various mechanisms and are thus an essential factor in …

Polysialic acid (PSA) serves as a hydrophilic polymer and affords conjugated biologically
active molecules a longer circulation time in vivo. Furthermore, PSA could potentially target …

Mononuclear phagocytes are efficient drug delivery targets for cancers owing to their
cancerous tissue-accumulating nature. As receptors of sialic acid, Siglecs (sialic acid …

Based on the knowledge that sialic acid is a critical element for tumor development and its
receptors are highly expressed on the tumor-associated macrophages (TAMs) which play …

Dexamethasone palmitate has the potential to inhibit the activity of tumor-associated
macrophages, which promote cancer proliferation, invasion, and metastasis; however, only …

Combined administration of drugs can improve efficacy and reduce toxicity; therefore, this
combination approach has become a routine method in cancer therapy. The main …

Malignant melanoma is a high-grade aggressive skin tumor with an increasing incidence
and mortality rates worldwide. Chemotherapeutic drugs such as doxorubicin have limited …