In order to survey a universe of major histocompatibility complex (MHC)-presented peptide
antigens whose numbers greatly exceed the diversity of the T cell repertoire, T cell receptors …

The promiscuous nature of T-cell receptors (TCRs) allows T cells to recognize a large variety
of pathogens, but makes it challenging to understand and control T-cell recognition. Existing …

T cell receptor (TCR) engagement of peptide-major histocompatibility complex (pMHC) is
essential to adaptive immunity, but it is unknown whether TCR signaling responses are …

The mammalian α/β T cell receptor (TCR) repertoire plays a pivotal role in adaptive immunity
by recognizing short, processed, peptide antigens bound in the context of a highly diverse …

Sensitivity, specificity, and context discrimination are three key properties of T cell antigen
recognition. T lymphocytes recognize antigen as peptides bound to major histocompatibility …

The T cell receptor (TCR) orchestrates immune responses by binding to foreign peptides
presented at the cell surface in the context of major histocompatibility complex (MHC) …

T-cell alloreactivity is a well-established phenomenon, but its molecular basis has remained
enigmatic. Although there are differences between T-cell recognition of conventional and …

ABSTRACT T-cell receptors recognize peptides presented by the major histocompatibility
complex (MHC) on the surface of antigen-presenting cells (APC). The ability of the T-cell …

TCR recognition of MHC/peptide complexes directs many aspects of T cell biology, including
thymic selection, survival of naı̈ve T cells and differentiation into effector and memory T …

T cells have to detect rare high-affinity 'foreign'peptide MHC (pMHC) ligands among
abundant low-affinity 'self'-peptide MHC ligands. It remains unclear how this remarkable …