Human cytomegalovirus (HCMV) is a member of the betaherpesvirus family that, unlike
other herpesviruses, triggers a strong innate immune response in infected cells that includes …

Previous studies have shown that human cytomegalovirus (CMV) is a potent elicitor of
interferon-stimulated gene (ISG) expression. Induction of the interferon pathway does not …

Human cytomegalovirus (HCMV) is a widespread pathogen that in immunocompromised
hosts can cause life-threatening disease. Studying HCMV-exposed monocyte-derived …

Viral infection activates interferon regulatory factor 3 (IRF3), a cofactor for the induction of
interferon-stimulated genes (ISGs). The role of IRF3 in the activation of ISGs by human …

Viruses are by far the most abundant parasites on earth and they have been found to infect
animals, plants and bacteria. However, different types of viruses can only infect a limited …

Cytomegaloviruses (CMV s) are master manipulators of the host immune response. Here,
we reveal that the murine CMV (MCMV) protein m152 specifically targets the type I interferon …

The antiviral activity of type I interferons (IFNs) is primarily mediated by interferon-stimulated
genes (ISGs). Induction of ISG transcription is achieved when type I IFNs bind to their …

Nuclear sensing of viral DNA has emerged as an essential step in innate immune responses
against herpesviruses. Here, we provide mechanistic insight into host recognition of human …

Human cytomegalovirus (hCMV) is a highly prevalent pathogen that, upon primary infection,
establishes life-long persistence in all infected individuals. Acute hCMV infections cause a …

The critical role of interferons (IFNs) in mediating the innate immune response to
cytomegalovirus (CMV) infection is well established. However, in recent years the functional …