Targeting ARID1A mutations in cancer
J Mullen, S Kato, JK Sicklick, R Kurzrock - Cancer treatment reviews, 2021 - Elsevier
Genes encoding SWI/SNF chromatin remodeling complex subunits are collectively mutated
in approximately 20% of human cancers. ARID1A is a SWI/SNF subunit gene whose protein …
in approximately 20% of human cancers. ARID1A is a SWI/SNF subunit gene whose protein …
ARID1A loss in cancer: towards a mechanistic understanding
R Mathur - Pharmacology & therapeutics, 2018 - Elsevier
Genes encoding subunits of SWI/SNF chromatin remodeling complexes are collectively
mutated in 20% of all human cancers. ARID1A is the SWI/SNF subunit gene that is most …
mutated in 20% of all human cancers. ARID1A is the SWI/SNF subunit gene that is most …
The emerging roles of ARID1A in tumor suppression
ARID1A has emerged as a tumor suppressor gene, which is mutated in a broad spectrum of
cancers, especially in those arising from ectopic or eutopic endometrium. As a subunit of …
cancers, especially in those arising from ectopic or eutopic endometrium. As a subunit of …
ARID1A deficiency impairs the DNA damage checkpoint and sensitizes cells to PARP inhibitors
Abstract ARID1A, SWI/SNF chromatin remodeling complex subunit, is a recently identified
tumor suppressor that is mutated in a broad spectrum of human cancers. Thus, it is of …
tumor suppressor that is mutated in a broad spectrum of human cancers. Thus, it is of …
Treating ARID1A mutated cancers by harnessing synthetic lethality and DNA damage response
Chromatin remodeling is an essential cellular process for organizing chromatin structure into
either open or close configuration at specific chromatin locations by orchestrating and …
either open or close configuration at specific chromatin locations by orchestrating and …
[HTML][HTML] ARID1A mutant ovarian clear cell carcinoma: A clear target for synthetic lethal strategies
JJ Caumanns, GBA Wisman, K Berns… - … et Biophysica Acta (BBA …, 2018 - Elsevier
SWI/SNF chromatin remodeling complexes play an important role in the epigenetic
regulation of chromatin structure and gene transcription. Mutual exclusive subunits in the …
regulation of chromatin structure and gene transcription. Mutual exclusive subunits in the …
ARID1A Mutations in Cancer: Another Epigenetic Tumor Suppressor?
JN Wu, CWM Roberts - Cancer discovery, 2013 - AACR
Although disordered chromatin organization has long been recognized as a feature of
cancer, the molecular underpinnings of chromatin structure, epigenetic regulation, and their …
cancer, the molecular underpinnings of chromatin structure, epigenetic regulation, and their …
Loss of ARID1A in tumor cells renders selective vulnerability to combined ionizing radiation and PARP inhibitor therapy
Purpose: Somatic inactivating mutations in ARID1A, a component of the SWI/SNF chromatin
remodeling complex, are detected in various types of human malignancies. Loss of ARID1A …
remodeling complex, are detected in various types of human malignancies. Loss of ARID1A …
[HTML][HTML] ARID1A gene mutation in ovarian and endometrial cancers
T Takeda, K Banno, R Okawa… - Oncology …, 2016 - spandidos-publications.com
The AT-rich interacting domain‑containing protein 1A gene (ARID1A) encodes ARID1A, a
member of the SWI/SNF chromatin remodeling complex. Mutation of ARID1A induces …
member of the SWI/SNF chromatin remodeling complex. Mutation of ARID1A induces …
ARID1A mutations in cancer development: mechanism and therapy
X Zhang, Y Zhang, J Zhao, Y Wu, N Zhang… - …, 2023 - academic.oup.com
Abstract AT-Rich Interaction Domain 1A (ARID1A) is an important SWItch/Sucrose Non-
Fermentation (SWI/SNF) chromatin remodeling complex subunit, and its coding gene has a …
Fermentation (SWI/SNF) chromatin remodeling complex subunit, and its coding gene has a …