Haematopoietic stem cells (HSCs) circulate in the bloodstream under steady-state
conditions, but the mechanisms controlling their physiological trafficking are unknown. Here …

Endogenous rhythmicity likely evolved as a mechanism allowing organisms to anticipate
predictable daily changes in the environment (Rutter et al., 2002). Under homeostasis …

Haematopoietic stem cells (HSCs) are widely studied by HSC transplantation into immune-
and blood-cell-depleted recipients. Single HSCs can rebuild the system after …

Circadian (∼ 24 hour) clocks are fundamentally important for coordinated physiology in
organisms as diverse as cyanobacteria and humans. All current models of the molecular …

Stem cells reside in a specialized, regulatory environment termed the niche that dictates
how they generate, maintain and repair tissues,. We have previously documented that …

Although haematopoietic stem cells (HSCs) are commonly assumed to reside within a
specialized microenvironment, or niche, most published experimental manipulations of the …

HAEMATOPOIETIC stem cells are a population of cells capable both of self renewal and of
differentiation into a variety of haematopoietic lineages1–4. Enrichment techniques of …

Haematopoietic stem cells (HSCs) reside in specialized microenvironments in the bone
marrow—often referred to as 'niches'—that represent complex regulatory milieux influenced …

Under stress conditions such as infection or inflammation the body rapidly needs to
generate new blood cells that are adapted to the challenge. Haematopoietic cytokines are …

Hematopoietic stem and progenitor cells (HSPCs) and leukocytes circulate between the
bone marrow (BM) and peripheral blood following circadian oscillations. Autonomic …