Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

CR Marshall, DP Howrigan, D Merico… - Nature …, 2017 - nature.com
Copy number variants (CNVs) have been strongly implicated in the genetic etiology of
schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk …

Copy number variation in schizophrenia in Sweden

JP Szatkiewicz, C O'Dushlaine, G Chen… - Molecular …, 2014 - nature.com
Schizophrenia (SCZ) is a highly heritable neuropsychiatric disorder of complex genetic
etiology. Previous genome-wide surveys have revealed a greater burden of large, rare copy …

Strong synaptic transmission impact by copy number variations in schizophrenia

JT Glessner, MP Reilly, CE Kim… - Proceedings of the …, 2010 - National Acad Sciences
Schizophrenia is a psychiatric disorder with onset in late adolescence and unclear etiology
characterized by both positive and negative symptoms, as well as cognitive deficits. To …

Analysis of intellectual disability copy number variants for association with schizophrenia

E Rees, K Kendall, AF Pardiñas, SE Legge… - JAMA …, 2016 - jamanetwork.com
Importance At least 11 rare copy number variants (CNVs) have been shown to be major risk
factors for schizophrenia (SZ). These CNVs also increase the risk for other …

Common variants conferring risk of schizophrenia

H Stefansson, RA Ophoff, S Steinberg, OA Andreassen… - Nature, 2009 - nature.com
Schizophrenia is a complex disorder, caused by both genetic and environmental factors and
their interactions. Research on pathogenesis has traditionally focused on neurotransmitter …

A genome-wide investigation of SNPs and CNVs in schizophrenia

AC Need, D Ge, ME Weale, J Maia, S Feng… - PLoS …, 2009 - journals.plos.org
We report a genome-wide assessment of single nucleotide polymorphisms (SNPs) and copy
number variants (CNVs) in schizophrenia. We investigated SNPs using 871 patients and …

Strong association of de novo copy number mutations with sporadic schizophrenia

B Xu, JL Roos, S Levy, EJ Van Rensburg, JA Gogos… - Nature …, 2008 - nature.com
Schizophrenia is an etiologically heterogeneous psychiatric disease, which exists in familial
and nonfamilial (sporadic) forms. Here, we examine the possibility that rare de novo copy …

Copy number variations in schizophrenia: critical review and new perspectives on concepts of genetics and disease

AS Bassett, SW Scherer… - American Journal of …, 2010 - Am Psychiatric Assoc
Objective Structural variations of DNA, such as copy number variations (CNVs), are
recognized to contribute both to normal genomic variability and to risk for human diseases …

Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function

S Raychaudhuri, JM Korn, SA McCarroll… - PLoS …, 2010 - journals.plos.org
Investigators have linked rare copy number variation (CNVs) to neuropsychiatric diseases,
such as schizophrenia. One hypothesis is that CNV events cause disease by affecting genes …

The role of DNA copy number variation in schizophrenia

GWC Tam, R Redon, NP Carter, SGN Grant - Biological psychiatry, 2009 - Elsevier
Schizophrenia is a major psychiatric disease with strong evidence of genetic risk factors.
Recent studies based on genome-wide study of copy number variations (CNVs) have …