Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
Copy number variants (CNVs) have been strongly implicated in the genetic etiology of
schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk …
schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk …
Copy number variation in schizophrenia in Sweden
JP Szatkiewicz, C O'Dushlaine, G Chen… - Molecular …, 2014 - nature.com
Schizophrenia (SCZ) is a highly heritable neuropsychiatric disorder of complex genetic
etiology. Previous genome-wide surveys have revealed a greater burden of large, rare copy …
etiology. Previous genome-wide surveys have revealed a greater burden of large, rare copy …
Strong synaptic transmission impact by copy number variations in schizophrenia
JT Glessner, MP Reilly, CE Kim… - Proceedings of the …, 2010 - National Acad Sciences
Schizophrenia is a psychiatric disorder with onset in late adolescence and unclear etiology
characterized by both positive and negative symptoms, as well as cognitive deficits. To …
characterized by both positive and negative symptoms, as well as cognitive deficits. To …
Analysis of intellectual disability copy number variants for association with schizophrenia
Importance At least 11 rare copy number variants (CNVs) have been shown to be major risk
factors for schizophrenia (SZ). These CNVs also increase the risk for other …
factors for schizophrenia (SZ). These CNVs also increase the risk for other …
Common variants conferring risk of schizophrenia
Schizophrenia is a complex disorder, caused by both genetic and environmental factors and
their interactions. Research on pathogenesis has traditionally focused on neurotransmitter …
their interactions. Research on pathogenesis has traditionally focused on neurotransmitter …
A genome-wide investigation of SNPs and CNVs in schizophrenia
We report a genome-wide assessment of single nucleotide polymorphisms (SNPs) and copy
number variants (CNVs) in schizophrenia. We investigated SNPs using 871 patients and …
number variants (CNVs) in schizophrenia. We investigated SNPs using 871 patients and …
Strong association of de novo copy number mutations with sporadic schizophrenia
Schizophrenia is an etiologically heterogeneous psychiatric disease, which exists in familial
and nonfamilial (sporadic) forms. Here, we examine the possibility that rare de novo copy …
and nonfamilial (sporadic) forms. Here, we examine the possibility that rare de novo copy …
Copy number variations in schizophrenia: critical review and new perspectives on concepts of genetics and disease
AS Bassett, SW Scherer… - American Journal of …, 2010 - Am Psychiatric Assoc
Objective Structural variations of DNA, such as copy number variations (CNVs), are
recognized to contribute both to normal genomic variability and to risk for human diseases …
recognized to contribute both to normal genomic variability and to risk for human diseases …
Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function
Investigators have linked rare copy number variation (CNVs) to neuropsychiatric diseases,
such as schizophrenia. One hypothesis is that CNV events cause disease by affecting genes …
such as schizophrenia. One hypothesis is that CNV events cause disease by affecting genes …
The role of DNA copy number variation in schizophrenia
GWC Tam, R Redon, NP Carter, SGN Grant - Biological psychiatry, 2009 - Elsevier
Schizophrenia is a major psychiatric disease with strong evidence of genetic risk factors.
Recent studies based on genome-wide study of copy number variations (CNVs) have …
Recent studies based on genome-wide study of copy number variations (CNVs) have …