Vascularization of reconstructed tissues is one of the remaining hurdles to be considered to
improve both the functionality and viability of skin grafts and the relevance of in vitro …

Full-thickness skin loss is a challenging problem due to limited reconstructive options,
demanding 75 million surgical procedures annually in the United States. Autologous skin …

INTRODUCTION: Skin substitutes are increasingly produced in tissue engineering, but still
the understanding of the physiological skin revascularization process is lacking. To study in …

Delayed or absence of vascularization is one of the major reasons for skin engraftment
failure in patients with extensive burns. For such trauma victims, the best alternative to a split …

Angiogenesis assays are essential for studying aspects of neovascularization and
angiogenesis and investigating drugs that stimulate or inhibit angiogenesis. To date, there …

Skin is a multilayer organ consisting of several tissues and appendages residing in a
complex niche. Adequate and physiologically regulated vascularization is an absolute …

Many types of skin substitutes have been constructed using exogenous materials.
Angiogenesis is an important factor for tissue‐engineered skin constructs. In this study, we …

A number of challenges in skin grafting for wound healing have drawn researchers to focus
on skin tissue engineering as an alternative solution. The core idea of tissue engineering is …

As the largest organ of the human body, the skin has a complex multi-layered structure. The
composition of the skin includes cells, extracellular matrix (ECM), vascular networks, and …

Tissue-engineered skin equivalents mimic key aspects of the human skin, and can thus be
employed as wound coverage for large skin defects or as in vitro test systems as an …