[HTML][HTML] A Narrative Literature Review on Sepsis: A Primary Manifestation of Colorectal Neoplasm

L Masood, A Müller, NZ Ali, A Mummadisetty, A Yahya… - Cureus, 2023 - ncbi.nlm.nih.gov
Sepsis and colorectal cancer (CRC) exhibit a complex relationship that warrants further
exploration. This review delves into the interplay of factors between sepsis and CRC …

[HTML][HTML] Transcriptome profiling of colorectal tumors from patients with sepsis reveals an ethnic basis for viral infection risk and sepsis progression

N Glibetic, YB Shvetsov, FJ Aan, K Peplowska… - Scientific Reports, 2022 - nature.com
Mortality from cancer-associated sepsis varies by cancer site and host responses to sepsis
are heterogenous. Native Hawaiians have the highest mortality risk from cancer-associated …

Gut microbiome in sepsis

NJ Klingensmith, CM Coopersmith - Surgical Infections, 2023 - liebertpub.com
The gut has been hypothesized to be the “motor” of multiple organ dysfunction in sepsis.
Although there are multiple ways in which the gut can drive systemic inflammation …

Gut microbes of the cecum versus the colon drive more severe lethality and multi-organ damage

K Xu, J Tan, D Lin, Y Chu, L Zhou, J Zhang, Y Lu Sr - bioRxiv, 2024 - biorxiv.org
An intestinal perforation or puncture leads to a high risk of sepsis-associated morbidity. A
perforation initiates the transfer of the intestinal contents (ICs) to the peritoneal cavity …

Sepsis: from pathophysiology to individualized patient care

I László, D Trásy, Z Molnár… - Journal of immunology …, 2015 - Wiley Online Library
Sepsis has become a major health economic issue, with more patients dying in hospitals
due to sepsis related complications compared to breast and colorectal cancer together …

Sepsis and the microbiome: a vicious cycle

WD Miller, R Keskey, JC Alverdy - The Journal of infectious …, 2021 - academic.oup.com
Sepsis has been characterized as a dysregulated host response to infection, and the role of
the microbiome as a key influencer of this response is emerging. Disruption of the …

Gut microbiome features are associated with sepsis onset and outcomes

K Rao, AR Patel, AM Seekatz, CM Bassis, Y Sun… - Biorxiv, 2021 - biorxiv.org
Background Epidemiologic studies have linked antibiotic exposure to subsequent sepsis,
suggesting that microbiome disruption may be in the causal pathway and an independent …

Cancer and sepsis

JC Williams, ML Ford, CM Coopersmith - Clinical Science, 2023 - portlandpress.com
Sepsis is one of the leading causes of death worldwide. While mortality is high regardless of
inciting infection or comorbidities, mortality in patients with cancer and sepsis is significantly …

The shift of an intestinal “microbiome” to a “pathobiome” governs the course and outcome of sepsis following surgical injury

MA Krezalek, J DeFazio, O Zaborina, A Zaborin… - Shock, 2016 - journals.lww.com
Sepsis following surgical injury remains a growing and worrisome problem following both
emergent and elective surgery. Although early resuscitation efforts and prompt antibiotic …

Enteric immunity, the gut microbiome, and sepsis: Rethinking the germ theory of disease

J Cabrera-Perez, VP Badovinac… - … Biology and Medicine, 2017 - journals.sagepub.com
Sepsis is a poorly understood syndrome of systemic inflammation responsible for hundreds
of thousands of deaths every year. The integrity of the gut epithelium and competence of …