Background Papillary thyroid carcinoma (PTC) is one of most prevalent malignant endocrine
neoplasms, and it is associated with a high frequency of BRAF gene mutations, which lead …

Abstract How the BRAF V600E mutation promotes the pathogenesis and aggressiveness of
papillary thyroid cancer (PTC) is not completely understood. Here we explored a novel …

Background BRAF mutation is one of the most common genetic alterations contributing to
the initiation and progression of papillary thyroid carcinoma (PTC). However, the prognostic …

Objective: This study aimed to clarify the function and potential mechanism of BUB1B in
THCA. Methods: Expression of BUB1B in THCA was firstly determined, and its important …

Background: WWP1 (WW domain-containing E3 ubiquitin protein ligase 1) is increased in
several kinds of carcinomas, but the influence of WWP1 in papillary thyroid cancer (PTC) is …

The mechanisms of B‐type Raf kinase (BRAF) V600E mutation in papillary thyroid cancer
(PTC) remain to be elucidated. With the aim to investigate the key candidate genes …

BRAFV600E mutation is the most frequent genetic alteration in papillary thyroid cancer
(PTC). β-Catenin (Ctnnb1) is a key downstream component of canonical Wnt signaling …

In this study, we aimed to investigate the biological functions of Tuftelin 1 (Tuft1) in thyroid
carcinoma (TC) and determine its underlying molecular mechanism. We found that the …

As the most common mutation in papillary thyroid cancer (PTC), B-type Raf kinase V600E
mutation (BRAF V600E) has become an important target for the clinical treatment of PTC …

Background Thyroid carcinoma (TC) has been a global issue for its rapid increasing
incidence worldwide. Although most TC was not so aggressive with a good prognosis …