Over the last five decades, a large body of evidence has accrued for structural and metabolic
brain alterations in schizophrenia. Here we provide an overview of these findings, focusing …

Synaptic dysfunction is hypothesised to play a key role in schizophrenia pathogenesis, but
this has not been tested directly in vivo. Here, we investigated synaptic vesicle glycoprotein …

Schizophrenia is associated with changes in the structure and functioning of a number of
key brain systems, including prefrontal and medial temporal lobe regions involved in …

The synaptic hypothesis of schizophrenia has been highly influential. However, new
approaches mean there has been a step-change in the evidence available, and some tenets …

One of the enduring puzzles about schizophrenia is the question of why it typically first
occurs in late adolescence or early adulthood. Structural neuroimaging studies indicate that …

In this review article we have consolidated the imaging literature of patients with
schizophrenia across the full spectrum of modalities in radiology including computed …

While functional neuroimaging studies on attention and executive function in schizophrenia
have reported several functionally aberrant cortical regions, less is known about the …

Abstract Since Emil Kraepelin's conceptualization of endogenous psychoses as dementia
praecox and manic depression, the separation between primary psychotic disorders and …

Voxel-based morphometry has recently been used successfully to detect gray matter volume
reductions in schizophrenic patients. The aim of the present study was to confirm the …

Schizophrenia is a devastating mental illness. Although its etiology is still largely unknown,
strides have been taken throughout the last several decades to elucidate the nature of the …