This review covers the molecular mechanisms involved in hair cell and hearing losses which
can result from trauma generated during the process of cochlear implantation and the …

Objectives: We describe the various molecular and cellular pathways that lead to early and
delayed loss of residual hearing after cochlear implantation. Methods: We performed a …

This study presents a novel in vitro model of electrode insertion trauma‐induced hair cell
(HC) damage and loss and its application for testing the efficacy of otoprotective drugs. In …

Conclusion: Programmed cell death (PCD) initially starts in the support cells (SCs) after
electrode insertion trauma (EIT), followed by PCD in hair cells (HCs). Activation of caspase-3 …

Conclusions A cocktail combining NAC, Mannitol, and Dexamethasone may be used to
prevent loss of residual hearing post-implantation. There is a window of opportunity to treat …

Background Following the loss of hair cells from the mammalian cochlea, the sensory
epithelium repairs to close the lesions but no new hair cells arise and hearing impairment …

Cochlear implantation trauma and noise‐induced hearing loss both involve a physical
disruption of the organ of Corti and may involve several mechanisms of cell death at the …

In the last few years progress has been made in understanding basic mechanisms involved
in damage to the inner ear and various potential therapeutic approaches have been …

Background Implantation of patients with residual hearing accentuates the need to preserve
functioning sensorineural elements. Although some auditory function may survive electrode …

Following the onset of sensorineural hearing loss, degeneration of mechanosensitive hair
cells and spiral ganglion cells (SGCs) in humans and animals occurs to variable degrees …