Westudied the effects of the methylxanthlnes, aminophylline (AMPH) and pentoxlfylline
(PTXF), on multiple organ damage following Escherichia coli sepsis In guinea pigs. To …

In several models of acute lung injury, it has been shown that methylxanthines that increase
intracellular cAMP by inhibiting cyclic nucleotide phosphodiesterase can attenuate the …

Objective: To determine the effects of pretreatment and posttreatment with pentoxifylline in a
porcine model of gram-negative sepsis. Design: Nonrandomized controlled trial. Study …

This study examines the changes in pulmonary leucostasis and capillary ultrastructure in 18
rabbits divided into three groups. Those in the first group were sham operated, and those in …

Pentoxifylline (PTXF), a drug demonstrated to improve intermittent claudication, is a
methylxanthlne that increases intracellular cyclic AMP (cAMP) and, unlike theophylline, has …

Abstract Background and Methods: Pentoxifylline can inhibit blood leukocyte functions in
vitro, and some inflammatory processes in the lung in vivo. Therefore, we examined the …

Phosphodiesterase inhibitors, such as pentoxifylline and aminophylline, may reduce
inflammatory cytokine-induced endothelial permeability. We tested the hypothesis that …

Effects of pentoxifylline on circulating cytokine concentrat... : Critical Care Medicine Effects of
pentoxifylline on circulating cytokine concentrations and hemodynamics in patients with septic …

Pentoxifylline improves bacterial clearance during hemorrhag... : Critical Care Medicine
Pentoxifylline improves bacterial clearance during hemorrhage and endotoxemia : Critical Care …

Recent evidence suggests that pentoxifylline (PTX) may be useful in the treatment of sepsis.
We examined effects of PTX in a conscious swine model of sepsis. Yucatan minipigs (20-30 …