By using fragments endowed with interesting and complementary properties for the
treatment of Alzheimer's disease (AD), a new family of tacrine–4-oxo-4 H-chromene hybrids …

Twenty-six new tacrine–benzofuran hybrids were designed, synthesized, and evaluated in
vitro on key molecular targets for Alzheimer's disease. Most hybrids exhibited good inhibitory …

A novel series of tacrine–caffeic acid hybrids (5a–f) were designed and synthesized by
combining caffeic acid (CA) with tacrine. The antioxidant study revealed that all the hybrids …

A novel series of tacrine derivatives were designed and synthesized by combining caffeic
acid (CA), ferulic acid (FA) and lipoic acid (LA) with tacrine. The antioxidant study revealed …

A novel series of acridine-chromenone and quinoline-chromenone hybrids were designed,
synthesized, and evaluated as anti-Alzheimer's agents. All synthesized compounds were …

A new series of tacrine–flavonoid hybrids (13a–u) had been designed, synthesized, and
evaluated as multifunctional cholinesterase (ChE) inhibitors against Alzheimer's disease …

Tacrine and PBT2 (an 8-hydroxyquinoline derivative) are well-known drugs that inhibit
cholinesterases and decrease β-amyloid (Aβ) levels by complexation of redox-active metals …

Five tacrine–ferulic acid hybrids (6a–e) were designed and synthesized as multi-potent anti-
Alzheimer drug candidates. All target compounds have better acetylcholinesterase inhibitory …

A series of tacrine-(β-carboline) hybrids (11a–q) were designed, synthesized and evaluated
as multifunctional cholinesterase inhibitors against Alzheimer's disease (AD). In vitro studies …

Combining tacrine with trolox in a single molecule, novel multifunctional hybrids have been
designed and synthesized. All these hybrids showed ChE inhibitory activity in nanomolar …