Retinoblastoma (Rb), the most frequent malignant intraocular tumor in childhood, is caused
by mutations in the retinoblastoma gene (RB1) situated on chromosome 13q14. 2. The …

Retinoblastoma (RB) is the most common intraocular cancer of infancy and childhood. This
cancer is initiated by mutation on RB1, the tumor suppressor gene that is responsible for the …

Retinoblastoma represents the prototypic model for inherited cancers. The RB1 gene was
the first tumor suppressor gene to be identified. It represents the most frequent primary eye …

With an average incidence of 1 in every 18,000 live births, retinoblastoma is a rare type of
intraocular tumour found to affect patients during their early childhood. It is curable if …

Summary Background: Retinoblastoma (Rb) is the most common primary malignant
intraocular tumour in childhood. The “two hit” theory, formulated by Knudson in 1971 to …

Purpose To review the progress made in understanding the genetic basis, molecular
pathology, and treatment of retinoblastoma since the previous Jackson lecture on the topic …

Retinoblastoma (Rb) is the most common primary ocular malignancy of children and is
caused by a mutation in the gene RB1. Approximately 40% of cases are associated with one …

Progressive advances in the understanding of retinoblastoma pathogenesis continue to lead
treatment strategies. Improvements in the diagnosis and management of retinoblastoma are …

Retinoblastoma is the commonest primary ocular malignancy of childhood. There are two
forms—heritable and non heritable. Heritable retinoblastoma is a cancer susceptibility …

Retinoblastoma is the prototype genetic cancer: in one or both eyes of young children, most
retinoblastomas are initiated by biallelic mutation of the retinoblastoma tumor suppressor …