In inflammatory, infectious, ischemic, and neurodegenerative pathologies of th central
nervous system (CNS) glia become “activated” by inflammatory mediators, and express new …

Glia undergo inflammatory activation in most CNS pathologies and are capable of killing
cocultured neurons. We investigated the mechanisms of this inflammatory …

Excessive generation of nitric oxide (NO) has been implicated in the pathogenesis of several
neurodegenerative disorders. Damage to the mitochondrial electron transport chain has …

Inflammation contributes to a wide variety of brain pathologies, apparently via glia killing
neurons. A number of mechanisms by which inflammatory-activated microglia and …

Inflammatory‐activated glia are seen in numerous central nervous system (CNS)
pathologies and can kill nearby neurons through the release of cytotoxic mediators. Glia …

NO and its derivatives can have multiple effects, which impact on neuronal death in different
ways. High levels of NO induces energy depletion-induced necrosis, due to:(i) rapid …

Inflammatory neurodegeneration contributes to a wide variety of brain pathologies. A
number of mechanisms by which inflammatory-activated microglia and astrocytes kill …

Within the CNS and under normal conditions, nitric oxide (• NO) appears to be an important
physiological signalling molecule. Its ability to increase cyclic GMP concentration suggests …

It is well established that glial cells have critical roles in the inflammatory processes in the
central nervous system (CNS). These cells can be activated by a variety of endogenous and …

Damage to the mitochondrial electron transport chain has been suggested to be an
important factor in the pathogenesis of a range of neurological disorders, such as …