Optical techniques have revolutionized the investigation of cardiac cellular physiology and
advanced our understanding of basic mechanisms of electrical activity, calcium …

Cardiac optical mapping has proven to be a powerful technology for studying cardiovascular
function and disease. The development and scientific impact of this methodology are well …

Optical mapping of cardiac excitation using voltage-and calcium-sensitive dyes has allowed
a unique view into excitation wave dynamics, and facilitated scientific discovery in the …

Cardiac optical mapping utilises fluorescent dyes to directly image the electrical function of
the heart at a high spatio-temporal resolution which far exceeds electrode techniques. It has …

BACKGROUND: Simultaneous optical mapping of multiple electrophysiologically relevant
parameters in living myocardium is desirable for integrative exploration of mechanisms …

Cardiac tissue is an excitable system that can support complex spatiotemporal dynamics,
including instabilities (arrhythmias) with lethal consequences. While over the last two …

The mouse heart is a popular model for cardiovascular studies due to the existence of low
cost technology for genetic engineering in this species. Cardiovascular physiological …

Two-photon excitation fluorescence imaging provides thin optical sections from deep within
thick, scattering specimens by way of restricting fluorophore excitation (and thus emission) to …

Optical mapping of Ca2+-sensitive fluorescence probes has become an extremely useful
approach and adopted by many cardiovascular research laboratories to study a spectrum of …

Optical mapping has become an increasingly important tool to study cardiac
electrophysiology in the past 20 years. Multiple methods are used to process and analyze …