[HTML][HTML] Characterizations of distinct parallel and antiparallel G-quadruplexes formed by two-repeat ALS and FTD related GGGGCC sequence
B Zhou, Y Geng, C Liu, H Miao, Y Ren, N Xu, X Shi… - Scientific reports, 2018 - nature.com
The large expansion of GGGGCC (G4C2) repeats of the C9orf72 gene have been found to
lead to the pathogenesis of devastating neurological diseases, amyotrophic lateral sclerosis …
lead to the pathogenesis of devastating neurological diseases, amyotrophic lateral sclerosis …
[HTML][HTML] Topology of a G-quadruplex DNA formed by C9orf72 hexanucleotide repeats associated with ALS and FTD
B Zhou, C Liu, Y Geng, G Zhu - Scientific reports, 2015 - nature.com
Abnormal expansions of an intronic hexanucleotide GGGGCC (G4C2) repeat of the C9orf72
gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and …
gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and …
Structural insight into C9orf72 hexanucleotide repeat expansions: Towards new therapeutic targets in FTD-ALS
Hexanucleotide repeat expansions,(G4C2) in the C9orf72 gene are considered as the
single most common genetic cause of both frontotemporal dementia (FTD) and amyotrophic …
single most common genetic cause of both frontotemporal dementia (FTD) and amyotrophic …
Crystal structure of parallel G-quadruplex formed by the two-repeat ALS-and FTD-related GGGGCC sequence
The hexanucleotide repeat expansion, GGGGCC (G4C2), within the first intron of the
C9orf72 gene is known to be the most common genetic cause of both amyotrophic lateral …
C9orf72 gene is known to be the most common genetic cause of both amyotrophic lateral …
[HTML][HTML] C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms RNA G-quadruplexes
Large expansions of a non-coding GGGGCC-repeat in the first intron of the C9orf72 gene
are a common cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal …
are a common cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal …
Solution structure of a DNA quadruplex containing ALS and FTD related GGGGCC repeat stabilized by 8-bromodeoxyguanosine substitution
J Brčić, J Plavec - Nucleic acids research, 2015 - academic.oup.com
A prolonged expansion of GGGGCC repeat within non-coding region of C9orf72 gene has
been identified as the most common cause of familial amyotrophic lateral sclerosis (ALS) …
been identified as the most common cause of familial amyotrophic lateral sclerosis (ALS) …
ALS and FTD linked GGGGCC-repeat containing DNA oligonucleotide folds into two distinct G-quadruplexes
J Brčić, J Plavec - Biochimica et Biophysica Acta (BBA)-General Subjects, 2017 - Elsevier
Background The most common genetic cause of neurological disorders ALS and FTD is a
largely increased number of GGGGCC repeats in C9orf72 gene. Non-canonical structures …
largely increased number of GGGGCC repeats in C9orf72 gene. Non-canonical structures …
NMR structure of a G-quadruplex formed by four d(G4C2) repeats: insights into structural polymorphism
J Brčić, J Plavec - Nucleic Acids Research, 2018 - academic.oup.com
Most frequent genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal
dementia (FTD), is a largely increased number of d (G4C2) n•(G2C4) n repeats located in …
dementia (FTD), is a largely increased number of d (G4C2) n•(G2C4) n repeats located in …
Characterization of DNA G-quadruplex species forming from C9ORF72 G4C2-expanded repeats associated with amyotrophic lateral sclerosis and frontotemporal …
P Šket, J Pohleven, A Kovanda, M Štalekar… - Neurobiology of …, 2015 - Elsevier
The G 4 C 2 hexanucleotide repeat expansion, located in the first intron of the C9ORF72
gene, represents a major genetic hallmark of amyotrophic lateral sclerosis and …
gene, represents a major genetic hallmark of amyotrophic lateral sclerosis and …
[HTML][HTML] The ALS/FTD-related C9orf72 hexanucleotide repeat expansion forms RNA condensates through multimolecular G-quadruplexes
F Raguseo, Y Wang, J Li, M Petrić Howe… - Nature …, 2023 - nature.com
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are
neurodegenerative diseases that exist on a clinico-pathogenetic spectrum, designated …
neurodegenerative diseases that exist on a clinico-pathogenetic spectrum, designated …