Asymmetric pendrin homodimer reveals its molecular mechanism as anion exchanger
Q Liu, X Zhang, H Huang, Y Chen, F Wang… - Nature …, 2023 - nature.com
Abstract Pendrin (SLC26A4) is an anion exchanger expressed in the apical membranes of
selected epithelia. Pendrin ablation causes Pendred syndrome, a genetic disorder …
selected epithelia. Pendrin ablation causes Pendred syndrome, a genetic disorder …
Mapping pathogenic mutations suggests an innovative structural model for the pendrin (SLC26A4) transmembrane domain
Abstract Human pendrin (SLC26A4) is an anion transporter mostly expressed in the inner
ear, thyroid and kidney. SLC26A4 gene mutations are associated with a broad phenotypic …
ear, thyroid and kidney. SLC26A4 gene mutations are associated with a broad phenotypic …
Molecular and functional characterization of human pendrin and its allelic variants
Abstract Pendrin (SLC26A4, PDS) is an electroneutral anion exchanger transporting I-, Cl-,
HCO3-, OH-, SCN-and formate. In the thyroid, pendrin is expressed at the apical membrane …
HCO3-, OH-, SCN-and formate. In the thyroid, pendrin is expressed at the apical membrane …
Pendrin: linking acid base to blood pressure
F Brazier, N Cornière, N Picard, R Chambrey… - … -European Journal of …, 2024 - Springer
Abstract Pendrin (SLC26A4) is an anion exchanger from the SLC26 transporter family which
is mutated in human patients affected by Pendred syndrome, an autosomal recessive …
is mutated in human patients affected by Pendred syndrome, an autosomal recessive …
The expression of wild-type pendrin (SLC26A4) in human embryonic kidney (HEK 293 Phoenix) cells leads to the activation of cationic currents
S Dossena, A Maccagni, V Vezzoli… - European journal of …, 2005 - academic.oup.com
Abstract Objective The SLC26A4 protein (pendrin) seems to be involved in the exchange of
chloride with other anions, therefore being responsible for iodide organification in the thyroid …
chloride with other anions, therefore being responsible for iodide organification in the thyroid …
Functional characterization of wild-type and mutated pendrin (SLC26A4), the anion transporter involved in Pendred syndrome.
S Dossena, S Rodighiero, V Vezzoli… - Journal of molecular …, 2009 - europepmc.org
Pendred syndrome (PS) is the most frequent form of genetically related syndromic hearing
loss, and is associated with mutations of pendrin, encoded by the SLC26A4 gene. This …
loss, and is associated with mutations of pendrin, encoded by the SLC26A4 gene. This …
[HTML][HTML] Regulation of the expression of the Cl-/anion exchanger pendrin in mouse kidney by acid-base status
Regulation of the expression of the Cl-/anion exchanger pendrin in mouse kidney by acid-
base status. Background Pendrin belongs to a superfamily of Cl-/anion exchangers and is …
base status. Background Pendrin belongs to a superfamily of Cl-/anion exchangers and is …
DOCA sensitive pendrin expression in kidney, heart, lung and thyroid tissues
Abstract Background/Aims: Pendrin (SLC26A4), a transporter accomplishing anion
exchange, is expressed in inner ear, thyroid gland, kidneys, lung, liver and heart. Loss or …
exchange, is expressed in inner ear, thyroid gland, kidneys, lung, liver and heart. Loss or …
Functional assessment of allelic variants in the SLC26A4 gene involved in Pendred syndrome and nonsyndromic EVA
Pendred syndrome is an autosomal recessive disorder characterized by sensorineural
hearing loss, with malformations of the inner ear, ranging from enlarged vestibular aqueduct …
hearing loss, with malformations of the inner ear, ranging from enlarged vestibular aqueduct …