The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis
EP Cummins, F Seeballuck, SJ Keely, NE Mangan… - Gastroenterology, 2008 - Elsevier
BACKGROUND & AIMS: Prolyl and asparaginyl hydroxylases are key oxygen-sensing
enzymes that confer hypoxic sensitivity to transcriptional regulatory pathways including the …
enzymes that confer hypoxic sensitivity to transcriptional regulatory pathways including the …
Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function
MM Tambuwala, EP Cummins, CR Lenihan, J Kiss… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: Hypoxia inducible factor (HIF) prolyl hydroxylase inhibitors are
protective in mouse models of inflammatory bowel disease (IBD). Here, we investigated the …
protective in mouse models of inflammatory bowel disease (IBD). Here, we investigated the …
Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition
A Robinson, S Keely, J Karhausen, ME Gerich… - Gastroenterology, 2008 - Elsevier
BACKGROUND & AIMS: A number of recent studies have implicated tissue hypoxia in both
acute and chronic inflammatory diseases, particularly as they relate to mucosal surfaces …
acute and chronic inflammatory diseases, particularly as they relate to mucosal surfaces …
[HTML][HTML] Hypoxia inducible factor (HIF) hydroxylases as regulators of intestinal epithelial barrier function
MC Manresa, CT Taylor - Cellular and molecular gastroenterology and …, 2017 - Elsevier
Human health is dependent on the ability of the body to extract nutrients, fluids, and oxygen
from the external environment while at the same time maintaining a state of internal sterility …
from the external environment while at the same time maintaining a state of internal sterility …
The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells
E Hams, SP Saunders, EP Cummins, A O'Connor… - Shock, 2011 - journals.lww.com
Localized tissue hypoxia is a feature of infection and inflammation, resulting in the
upregulation of the transcription factors hypoxia-inducible factor 1α and nuclear factor κB …
upregulation of the transcription factors hypoxia-inducible factor 1α and nuclear factor κB …
Targeted delivery of the hydroxylase inhibitor DMOG provides enhanced efficacy with reduced systemic exposure in a murine model of colitis
MM Tambuwala, MC Manresa, EP Cummins… - Journal of Controlled …, 2015 - Elsevier
Targeting hypoxia-sensitive pathways has recently been proposed as a new therapeutic
approach to the treatment of intestinal inflammation. HIF-hydroxylases are enzymes which …
approach to the treatment of intestinal inflammation. HIF-hydroxylases are enzymes which …
[HTML][HTML] Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis
Pharmacological stabilization of hypoxia-inducible factor (HIF) through prolyl hydroxylase
(PHD) inhibition limits mucosal damage associated with models of murine colitis. However …
(PHD) inhibition limits mucosal damage associated with models of murine colitis. However …
Hydroxylase inhibition abrogates TNF-α–induced intestinal epithelial damage by hypoxia-inducible factor-1–dependent repression of FADD
P Hindryckx, M De Vos, P Jacques… - The Journal of …, 2010 - journals.aai.org
Hydroxylase inhibitors stabilize hypoxia-inducible factor-1 (HIF-1), which has barrier-
protective activity in the gut. Because the inflammatory cytokine TNF-α contributes to …
protective activity in the gut. Because the inflammatory cytokine TNF-α contributes to …
Dynamics of prolyl hydroxylases levels during disease progression in experimental colitis
Hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) inhibitors are shown to be protective
in several models of inflammatory bowel disease (IBD). However, these non-selective …
in several models of inflammatory bowel disease (IBD). However, these non-selective …
Oral delivery of prolyl hydroxylase inhibitor: AKB-4924 promotes localized mucosal healing in a mouse model of colitis
E Marks, BJ Goggins, J Cardona, S Cole… - Inflammatory bowel …, 2015 - academic.oup.com
Background Pharmacological induction of hypoxia-inducible factor (HIF), a global
transcriptional regulator of the hypoxic response, by prolyl hydroxylase inhibitors (PHDi) is …
transcriptional regulator of the hypoxic response, by prolyl hydroxylase inhibitors (PHDi) is …